Intragastric and Intranasal Administration of Lactobacillus paracasei NCC2461 Modulates Allergic Airway Inflammation in Mice
Joint Authors
Barbier, Nathalie
Boudousquié, Caroline
Blanchard, Carine
Thierry, Anne-Christine
Pellaton, Céline
Mercenier, Annick
Nutten, Sophie
Spertini, François
Corthésy, Blaise
Source
International Journal of Inflammation
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Preclinical and clinical evidences for a role of oral probiotics in the management of allergic diseases are emerging.
Aim.
We aimed at testing the immunomodulatory effects of intranasal versus intragastric administration of Lactobacillus paracasei NCC2461 in a mouse model of allergic airway inflammation and the specificity of different probiotics by comparing L.
paracasei NCC2461 to Lactobacillus plantarum NCC1107.
Methods.
L.
paracasei NCC2461 or L.
plantarum NCC1107 strains were administered either intragastrically (NCC2461) or intranasally (NCC2461 or NCC1107) to OVA-sensitized mice challenged with OVA aerosols.
Inflammatory cell recruitment into BALF, eotaxin and IL-5 production in the lungs were measured.
Results.
Intranasal L.
paracasei NCC2461 efficiently protected sensitized mice upon exposure to OVA aerosols in a dose-dependent manner as compared to control mice.
Inflammatory cell number, eotaxin and IL-5 were significantly reduced in BALF.
Intranasal supplementation of L.
paracasei NCC2461 was more potent than intragastric application in limiting the allergic response and possibly linked to an increase in T regulatory cells in the lungs.
Finally, intranasal L.
plantarum NCC1107 reduced total and eosinophilic lung inflammation, but increased neutrophilia and macrophages infiltration.
Conclusion.
A concerted selection of intervention schedule, doses, and administration routes (intranasal versus intragastric) may markedly contribute to modulate airway inflammation in a probiotic strain-specific manner.
American Psychological Association (APA)
Pellaton, Céline& Nutten, Sophie& Thierry, Anne-Christine& Boudousquié, Caroline& Barbier, Nathalie& Blanchard, Carine…[et al.]. 2012. Intragastric and Intranasal Administration of Lactobacillus paracasei NCC2461 Modulates Allergic Airway Inflammation in Mice. International Journal of Inflammation،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-490573
Modern Language Association (MLA)
Pellaton, Céline…[et al.]. Intragastric and Intranasal Administration of Lactobacillus paracasei NCC2461 Modulates Allergic Airway Inflammation in Mice. International Journal of Inflammation No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-490573
American Medical Association (AMA)
Pellaton, Céline& Nutten, Sophie& Thierry, Anne-Christine& Boudousquié, Caroline& Barbier, Nathalie& Blanchard, Carine…[et al.]. Intragastric and Intranasal Administration of Lactobacillus paracasei NCC2461 Modulates Allergic Airway Inflammation in Mice. International Journal of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-490573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490573