Pomegranate Fruit as a Rich Source of Biologically Active Compounds
المؤلفون المشاركون
Sithul, Hima
Muraleedharan, Parvathy
Azeez, Juberiya Mohammed
Sreeharshan, Sreeja
Sreekumar, Sreeja
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-10
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Pomegranate is a widely used plant having medicinal properties.
In this review, we have mainly focused on the already published data from our laboratory pertaining to the effect of methanol extract of pericarp of pomegranate (PME) and have compared it with other relevant literatures on Punica.
Earlier, we had shown its antiproliferative effect using human breast (MCF-7, MDA MB-231), and endometrial (HEC-1A), cervical (SiHa, HeLa), and ovarian (SKOV3) cancer cell lines, and normal breast fibroblasts (MCF-10A) at concentration of 20–320 μg/mL.
The expressions of selected estrogen responsive genes (PR, pS2, and C-Myc) were downregulated by PME.
Unlike estradiol, PME did not increase the uterine weight and proliferation in bilaterally ovariectomized Swiss-Albino mice models and its cardioprotective effects were comparable to that of 17β-estradiol.
We had further assessed the protective role of PME on skeletal system, using MC3T3-E1 cells.
The results indicated that PME (80 μg/mL) significantly increased ALP (Alkaline Phosphatase) activity, supporting its suggested role in modulating osteoblastic cell differentiation.
The antiosteoporotic potential of PME was also evaluated in ovariectomized (OVX) rodent model.
The results from our studies and from various other studies support the fact that pomegranate fruit is indeed a source of biologically active compounds.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sreekumar, Sreeja& Sithul, Hima& Muraleedharan, Parvathy& Azeez, Juberiya Mohammed& Sreeharshan, Sreeja. 2014. Pomegranate Fruit as a Rich Source of Biologically Active Compounds. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-490585
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sreekumar, Sreeja…[et al.]. Pomegranate Fruit as a Rich Source of Biologically Active Compounds. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-490585
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sreekumar, Sreeja& Sithul, Hima& Muraleedharan, Parvathy& Azeez, Juberiya Mohammed& Sreeharshan, Sreeja. Pomegranate Fruit as a Rich Source of Biologically Active Compounds. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-490585
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490585
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر