![](/images/graphics-bg.png)
Pomegranate Fruit as a Rich Source of Biologically Active Compounds
Joint Authors
Sithul, Hima
Muraleedharan, Parvathy
Azeez, Juberiya Mohammed
Sreeharshan, Sreeja
Sreekumar, Sreeja
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Pomegranate is a widely used plant having medicinal properties.
In this review, we have mainly focused on the already published data from our laboratory pertaining to the effect of methanol extract of pericarp of pomegranate (PME) and have compared it with other relevant literatures on Punica.
Earlier, we had shown its antiproliferative effect using human breast (MCF-7, MDA MB-231), and endometrial (HEC-1A), cervical (SiHa, HeLa), and ovarian (SKOV3) cancer cell lines, and normal breast fibroblasts (MCF-10A) at concentration of 20–320 μg/mL.
The expressions of selected estrogen responsive genes (PR, pS2, and C-Myc) were downregulated by PME.
Unlike estradiol, PME did not increase the uterine weight and proliferation in bilaterally ovariectomized Swiss-Albino mice models and its cardioprotective effects were comparable to that of 17β-estradiol.
We had further assessed the protective role of PME on skeletal system, using MC3T3-E1 cells.
The results indicated that PME (80 μg/mL) significantly increased ALP (Alkaline Phosphatase) activity, supporting its suggested role in modulating osteoblastic cell differentiation.
The antiosteoporotic potential of PME was also evaluated in ovariectomized (OVX) rodent model.
The results from our studies and from various other studies support the fact that pomegranate fruit is indeed a source of biologically active compounds.
American Psychological Association (APA)
Sreekumar, Sreeja& Sithul, Hima& Muraleedharan, Parvathy& Azeez, Juberiya Mohammed& Sreeharshan, Sreeja. 2014. Pomegranate Fruit as a Rich Source of Biologically Active Compounds. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-490585
Modern Language Association (MLA)
Sreekumar, Sreeja…[et al.]. Pomegranate Fruit as a Rich Source of Biologically Active Compounds. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-490585
American Medical Association (AMA)
Sreekumar, Sreeja& Sithul, Hima& Muraleedharan, Parvathy& Azeez, Juberiya Mohammed& Sreeharshan, Sreeja. Pomegranate Fruit as a Rich Source of Biologically Active Compounds. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-490585
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490585