Amyloid Beta Annular Protofibrils in Cell Processes and Synapses Accumulate with Aging and Alzheimer-Associated Genetic Modification

المؤلفون المشاركون

Kokubo, Hideko
Glabe, Charles G.
Saido, Takaomi C.
Staufenbiel, Matthias
Kayed, Rakez
Yamaguchi, Haruyasu
Iwata, Nobuhisa

المصدر

International Journal of Alzheimer's Disease

العدد

المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2009-07-14

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Amyloid β (Aβ) annular protofibrils (APFs) have been described where the structure is related to that of β barrel pore-forming bacterial toxins and exhibits cellular toxicity.

To investigate the relationship of Aβ APFs to disease and their ultrastructural localization in brain tissue, we conducted a pre-embedding immunoelectron microscopic study using anti-annular protofibril antiserum.

We examined brain tissues of young- and old-aged amyloid precursor protein transgenic mice (APP23), neprilysin knockout APP23 mice, and nontransgenic littermates.

αAPF-immunoreactions tended to be found (1) on plasma membranes and vesicles inside of cell processes, but not on amyloid fibrils, (2) with higher density due to aging, APP transgene, and neprilysin deficiency, and (3) with higher positive rate at synaptic compartments in aged APP23, especially in neprilysin knockout APP23 mice.

These findings imply that APFs are distinct from amyloid fibrils, interact with biological membranes, and might be related to synaptic dysfunction in Alzheimer model mouse brains.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Kokubo, Hideko& Kayed, Rakez& Glabe, Charles G.& Staufenbiel, Matthias& Saido, Takaomi C.& Iwata, Nobuhisa…[et al.]. 2009. Amyloid Beta Annular Protofibrils in Cell Processes and Synapses Accumulate with Aging and Alzheimer-Associated Genetic Modification. International Journal of Alzheimer's Disease،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-490712

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Kokubo, Hideko…[et al.]. Amyloid Beta Annular Protofibrils in Cell Processes and Synapses Accumulate with Aging and Alzheimer-Associated Genetic Modification. International Journal of Alzheimer's Disease No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-490712

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Kokubo, Hideko& Kayed, Rakez& Glabe, Charles G.& Staufenbiel, Matthias& Saido, Takaomi C.& Iwata, Nobuhisa…[et al.]. Amyloid Beta Annular Protofibrils in Cell Processes and Synapses Accumulate with Aging and Alzheimer-Associated Genetic Modification. International Journal of Alzheimer's Disease. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-490712

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-490712