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A Systematic Follow-Up of Mycobacterium tuberculosis Drug-Resistance and Associated Genotypic Lineages in the French Departments of the Americas over a Seventeen-Year Period
المؤلفون المشاركون
Schuster, Franziska
Berchel, Mylène
Vanhomwegen, Jessica
Bomer, Anne-Gaël
Millet, Julie
Paasch, Delaina
Rastogi, Nalin
Streit, Elisabeth
Cadelis, Gilbert
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-13
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The population of the French Departments of the Americas (FDA) is highly influenced by the intense migratory flows with mainland France and surrounding countries of the Caribbean and Latin America, some of which have high incidence rates of tuberculosis (Haiti: 230/100,000; Guyana: 111/100,000; and Suriname: 145/100,000) and drug resistance.
Since the development of drug resistance to conventional antituberculous drugs has a major impact on the treatment success of tuberculosis, we therefore decided to review carefully Mycobacterium tuberculosis drug resistance and associated genotypic lineages in the FDA over a seventeen-year period (January 1995–December 2011).
A total of 1239 cases were studied, including 153 drug-resistant and 26 multidrug-resistant- (MDR-) TB cases, representing 12.3% and 2.1% of the TB cases in our study setting.
A significantly higher proportion of M.
tuberculosis isolates among relapse cases showed drug resistance to isoniazid (22.5%, P=0.002), rifampicin (20.0%, P<0.001), or both (MDR-TB, 17.5%; P<0.001).
Determination of spoligotyping based phylogenetic clades showed that among the five major lineages observed—T family (30.1%); Latin-American and Mediterranean (LAM, 23.7%); Haarlem (H, 22.2%); East-African Indian (EAI, 7.2%); and X family (6.5%)—two lineages, X and LAM, were overrepresented in drug-resistant and MDR-TB cases, respectively.
Finally, 19 predominant spoligotypes were identified for the 1239 isolates of M.
tuberculosis in our study among which 4 were significantly associated with drug resistance corresponding to SIT20/LAM1, SIT64/LAM6, SIT45/H1, and SIT46/undefined lineage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Millet, Julie& Streit, Elisabeth& Berchel, Mylène& Bomer, Anne-Gaël& Schuster, Franziska& Paasch, Delaina…[et al.]. 2014. A Systematic Follow-Up of Mycobacterium tuberculosis Drug-Resistance and Associated Genotypic Lineages in the French Departments of the Americas over a Seventeen-Year Period. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-490774
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Millet, Julie…[et al.]. A Systematic Follow-Up of Mycobacterium tuberculosis Drug-Resistance and Associated Genotypic Lineages in the French Departments of the Americas over a Seventeen-Year Period. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-490774
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Millet, Julie& Streit, Elisabeth& Berchel, Mylène& Bomer, Anne-Gaël& Schuster, Franziska& Paasch, Delaina…[et al.]. A Systematic Follow-Up of Mycobacterium tuberculosis Drug-Resistance and Associated Genotypic Lineages in the French Departments of the Americas over a Seventeen-Year Period. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-490774
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490774
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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