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A Systematic Follow-Up of Mycobacterium tuberculosis Drug-Resistance and Associated Genotypic Lineages in the French Departments of the Americas over a Seventeen-Year Period
Joint Authors
Schuster, Franziska
Berchel, Mylène
Vanhomwegen, Jessica
Bomer, Anne-Gaël
Millet, Julie
Paasch, Delaina
Rastogi, Nalin
Streit, Elisabeth
Cadelis, Gilbert
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-13
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The population of the French Departments of the Americas (FDA) is highly influenced by the intense migratory flows with mainland France and surrounding countries of the Caribbean and Latin America, some of which have high incidence rates of tuberculosis (Haiti: 230/100,000; Guyana: 111/100,000; and Suriname: 145/100,000) and drug resistance.
Since the development of drug resistance to conventional antituberculous drugs has a major impact on the treatment success of tuberculosis, we therefore decided to review carefully Mycobacterium tuberculosis drug resistance and associated genotypic lineages in the FDA over a seventeen-year period (January 1995–December 2011).
A total of 1239 cases were studied, including 153 drug-resistant and 26 multidrug-resistant- (MDR-) TB cases, representing 12.3% and 2.1% of the TB cases in our study setting.
A significantly higher proportion of M.
tuberculosis isolates among relapse cases showed drug resistance to isoniazid (22.5%, P=0.002), rifampicin (20.0%, P<0.001), or both (MDR-TB, 17.5%; P<0.001).
Determination of spoligotyping based phylogenetic clades showed that among the five major lineages observed—T family (30.1%); Latin-American and Mediterranean (LAM, 23.7%); Haarlem (H, 22.2%); East-African Indian (EAI, 7.2%); and X family (6.5%)—two lineages, X and LAM, were overrepresented in drug-resistant and MDR-TB cases, respectively.
Finally, 19 predominant spoligotypes were identified for the 1239 isolates of M.
tuberculosis in our study among which 4 were significantly associated with drug resistance corresponding to SIT20/LAM1, SIT64/LAM6, SIT45/H1, and SIT46/undefined lineage.
American Psychological Association (APA)
Millet, Julie& Streit, Elisabeth& Berchel, Mylène& Bomer, Anne-Gaël& Schuster, Franziska& Paasch, Delaina…[et al.]. 2014. A Systematic Follow-Up of Mycobacterium tuberculosis Drug-Resistance and Associated Genotypic Lineages in the French Departments of the Americas over a Seventeen-Year Period. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-490774
Modern Language Association (MLA)
Millet, Julie…[et al.]. A Systematic Follow-Up of Mycobacterium tuberculosis Drug-Resistance and Associated Genotypic Lineages in the French Departments of the Americas over a Seventeen-Year Period. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-490774
American Medical Association (AMA)
Millet, Julie& Streit, Elisabeth& Berchel, Mylène& Bomer, Anne-Gaël& Schuster, Franziska& Paasch, Delaina…[et al.]. A Systematic Follow-Up of Mycobacterium tuberculosis Drug-Resistance and Associated Genotypic Lineages in the French Departments of the Americas over a Seventeen-Year Period. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-490774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490774