![](/images/graphics-bg.png)
The M. tuberculosis Phosphate-Binding Lipoproteins PstS1 and PstS3 Induce Th1 and Th17 Responses That Are Not Associated with Protection against M. tuberculosis Infection
المؤلفون المشاركون
Piccaro, Giovanni
Pardini, Manuela
Cassone, Antonio
Jonas, Fatima
Spallek, Ralf
Singh, Mahavir
Oehlmann, Wulf
Palma, Carla
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-03-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The M.
tuberculosis phosphate-binding transporter lipoproteins PstS1 and PstS3 were good immunogens inducing CD8+ T-cell activation and both Th1 and Th17 immunity in mice.
However, this antigen-specific immunity, even when amplified by administration of the protein with the adjuvant LTK63 or by the DNA priming/protein boosting regimen, was not able to contain M.
tuberculosis replication in the lungs of infected mice.
The lack of protection might be ascribed with the scarce/absent capacity of PstS1/PstS3 antigens to modulate the IFN-γ response elicited by M.
tuberculosis infection during which, however, PstS1-specific IL-17 secreting cells were generated in both unvaccinated and BCG-vaccinated mice.
In spite of a lack of protection by PstS1/PstS3 immunizations, our results do show that PstS1 is able to induce IL-17 response upon M.
tuberculosis infection which is of interest in the study of anti-M.
tuberculosis immunity and as potential immunomodulator in combined vaccines.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Palma, Carla& Spallek, Ralf& Piccaro, Giovanni& Pardini, Manuela& Jonas, Fatima& Oehlmann, Wulf…[et al.]. 2011. The M. tuberculosis Phosphate-Binding Lipoproteins PstS1 and PstS3 Induce Th1 and Th17 Responses That Are Not Associated with Protection against M. tuberculosis Infection. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-490802
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Palma, Carla…[et al.]. The M. tuberculosis Phosphate-Binding Lipoproteins PstS1 and PstS3 Induce Th1 and Th17 Responses That Are Not Associated with Protection against M. tuberculosis Infection. Clinical and Developmental Immunology No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-490802
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Palma, Carla& Spallek, Ralf& Piccaro, Giovanni& Pardini, Manuela& Jonas, Fatima& Oehlmann, Wulf…[et al.]. The M. tuberculosis Phosphate-Binding Lipoproteins PstS1 and PstS3 Induce Th1 and Th17 Responses That Are Not Associated with Protection against M. tuberculosis Infection. Clinical and Developmental Immunology. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-490802
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490802
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)