The M. tuberculosis Phosphate-Binding Lipoproteins PstS1 and PstS3 Induce Th1 and Th17 Responses That Are Not Associated with Protection against M. tuberculosis Infection
Joint Authors
Piccaro, Giovanni
Pardini, Manuela
Cassone, Antonio
Jonas, Fatima
Spallek, Ralf
Singh, Mahavir
Oehlmann, Wulf
Palma, Carla
Source
Clinical and Developmental Immunology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The M.
tuberculosis phosphate-binding transporter lipoproteins PstS1 and PstS3 were good immunogens inducing CD8+ T-cell activation and both Th1 and Th17 immunity in mice.
However, this antigen-specific immunity, even when amplified by administration of the protein with the adjuvant LTK63 or by the DNA priming/protein boosting regimen, was not able to contain M.
tuberculosis replication in the lungs of infected mice.
The lack of protection might be ascribed with the scarce/absent capacity of PstS1/PstS3 antigens to modulate the IFN-γ response elicited by M.
tuberculosis infection during which, however, PstS1-specific IL-17 secreting cells were generated in both unvaccinated and BCG-vaccinated mice.
In spite of a lack of protection by PstS1/PstS3 immunizations, our results do show that PstS1 is able to induce IL-17 response upon M.
tuberculosis infection which is of interest in the study of anti-M.
tuberculosis immunity and as potential immunomodulator in combined vaccines.
American Psychological Association (APA)
Palma, Carla& Spallek, Ralf& Piccaro, Giovanni& Pardini, Manuela& Jonas, Fatima& Oehlmann, Wulf…[et al.]. 2011. The M. tuberculosis Phosphate-Binding Lipoproteins PstS1 and PstS3 Induce Th1 and Th17 Responses That Are Not Associated with Protection against M. tuberculosis Infection. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-490802
Modern Language Association (MLA)
Palma, Carla…[et al.]. The M. tuberculosis Phosphate-Binding Lipoproteins PstS1 and PstS3 Induce Th1 and Th17 Responses That Are Not Associated with Protection against M. tuberculosis Infection. Clinical and Developmental Immunology No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-490802
American Medical Association (AMA)
Palma, Carla& Spallek, Ralf& Piccaro, Giovanni& Pardini, Manuela& Jonas, Fatima& Oehlmann, Wulf…[et al.]. The M. tuberculosis Phosphate-Binding Lipoproteins PstS1 and PstS3 Induce Th1 and Th17 Responses That Are Not Associated with Protection against M. tuberculosis Infection. Clinical and Developmental Immunology. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-490802
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490802