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Protective Effects of Lycium barbarum Polysaccharides on Testis Spermatogenic Injury Induced by Bisphenol A in Mice
المؤلفون المشاركون
Zhao, Xinghua
Zhang, Caili
Li, Shuang
Sun, Xiaona
Li, Xiaocai
Wang, Anzhong
Ma, Aituan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
To observe the effects of Lycium barbarum polysaccharides (LBP) on testis spermatogenic injuries induced by Bisphenol A (BPA) in mice.
BPA was subcutaneously injected into mice at a dose of 20 mg/kg body weight (BW) for 7 consecutive days.
LBP was administered simultaneously with BPA by gavage daily at the dose of 50, 100, and 200 mg/kg BW for 7 days.
After treatment, the weight and the histopathology changes of testis and epididymis were examined; the contents of T, LH, GnRH, antioxidant enzyme, and malondialdehyde (MDA) in serum were detected; proapoptotic protein Bax and antiapoptotic protein Bcl-2 were also detected by immunohistochemical method.
Results showed that the weights of testis and epididymis were all increased after supplement with different dosages of LBP compared with BPA group, and the activities of SOD and GSH-Px were significantly increased in LBP groups, while MDA contents were gradually decreased.
Moreover, the levels of T, LH, and GnRH were significantly elevated in serum treated with 100 mg/kg LBP.
LBP also shows significant positive effects on the expression of Bcl-2/Bax in BPA treated mice.
It is concluded that LBP may be one of the potential ingredients protecting the adult male animals from BPA induced reproductive damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Caili& Wang, Anzhong& Sun, Xiaona& Li, Xiaocai& Zhao, Xinghua& Li, Shuang…[et al.]. 2013. Protective Effects of Lycium barbarum Polysaccharides on Testis Spermatogenic Injury Induced by Bisphenol A in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-490859
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Caili…[et al.]. Protective Effects of Lycium barbarum Polysaccharides on Testis Spermatogenic Injury Induced by Bisphenol A in Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-490859
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Caili& Wang, Anzhong& Sun, Xiaona& Li, Xiaocai& Zhao, Xinghua& Li, Shuang…[et al.]. Protective Effects of Lycium barbarum Polysaccharides on Testis Spermatogenic Injury Induced by Bisphenol A in Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-490859
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490859
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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