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Protective Effects of Lycium barbarum Polysaccharides on Testis Spermatogenic Injury Induced by Bisphenol A in Mice
Joint Authors
Zhao, Xinghua
Zhang, Caili
Li, Shuang
Sun, Xiaona
Li, Xiaocai
Wang, Anzhong
Ma, Aituan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
To observe the effects of Lycium barbarum polysaccharides (LBP) on testis spermatogenic injuries induced by Bisphenol A (BPA) in mice.
BPA was subcutaneously injected into mice at a dose of 20 mg/kg body weight (BW) for 7 consecutive days.
LBP was administered simultaneously with BPA by gavage daily at the dose of 50, 100, and 200 mg/kg BW for 7 days.
After treatment, the weight and the histopathology changes of testis and epididymis were examined; the contents of T, LH, GnRH, antioxidant enzyme, and malondialdehyde (MDA) in serum were detected; proapoptotic protein Bax and antiapoptotic protein Bcl-2 were also detected by immunohistochemical method.
Results showed that the weights of testis and epididymis were all increased after supplement with different dosages of LBP compared with BPA group, and the activities of SOD and GSH-Px were significantly increased in LBP groups, while MDA contents were gradually decreased.
Moreover, the levels of T, LH, and GnRH were significantly elevated in serum treated with 100 mg/kg LBP.
LBP also shows significant positive effects on the expression of Bcl-2/Bax in BPA treated mice.
It is concluded that LBP may be one of the potential ingredients protecting the adult male animals from BPA induced reproductive damage.
American Psychological Association (APA)
Zhang, Caili& Wang, Anzhong& Sun, Xiaona& Li, Xiaocai& Zhao, Xinghua& Li, Shuang…[et al.]. 2013. Protective Effects of Lycium barbarum Polysaccharides on Testis Spermatogenic Injury Induced by Bisphenol A in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-490859
Modern Language Association (MLA)
Zhang, Caili…[et al.]. Protective Effects of Lycium barbarum Polysaccharides on Testis Spermatogenic Injury Induced by Bisphenol A in Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-490859
American Medical Association (AMA)
Zhang, Caili& Wang, Anzhong& Sun, Xiaona& Li, Xiaocai& Zhao, Xinghua& Li, Shuang…[et al.]. Protective Effects of Lycium barbarum Polysaccharides on Testis Spermatogenic Injury Induced by Bisphenol A in Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-490859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490859