Peroxisome Proliferator-Activated Receptors Alpha, Beta, and Gamma mRNA and Protein Expression in Human Fetal Tissues

المؤلفون المشاركون

Watkins, Andrew M.
Das, Kaberi P.
Wood, Carmen R.
Abbott, Barbara D.
Lau, Christopher S.

المصدر

PPAR Research

العدد

المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-19، 19ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2010-07-26

دولة النشر

مصر

عدد الصفحات

19

التخصصات الرئيسية

العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء

الملخص EN

Peroxisome proliferator-activated receptors (PPARs) regulate lipid and glucose homeostasis, are targets of pharmaceuticals, and are also activated by environmental contaminants.

Almost nothing is known about expression of PPARs during human fetal development.

This study examines expression of PPARα, β, and γ mRNA and protein in human fetal tissues.

With increasing fetal age, mRNA expression of PPARα and β increased in liver, but PPARβ decreased in heart and intestine, and PPARγ decreased in adrenal.

Adult and fetal mean expression of PPARα, β, and γ mRNA did not differ in intestine, but expression was lower in fetal stomach and heart.

PPARα and β mRNA in kidney and spleen, and PPARγ mRNA in lung and adrenal were lower in fetal versus adult.

PPARγ in liver and PPARβ mRNA in thymus were higher in fetal versus adult.

PPARα protein increased with fetal age in intestine and decreased in lung, kidney, and adrenal.

PPARβ protein in adrenal and PPARγ in kidney decreased with fetal age.

This study provides new information on expression of PPAR subtypes during human development and will be important in evaluating the potential for the developing human to respond to PPAR environmental or pharmaceutical agonists.Erratum to “Peroxisome Proliferator-Activated Receptors Alpha, Beta, and Gamma mRNA and Protein Expression in Human Fetal Tissues”dx.doi.org/10.1155/2010/627284

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Abbott, Barbara D.& Wood, Carmen R.& Watkins, Andrew M.& Das, Kaberi P.& Lau, Christopher S.. 2010. Peroxisome Proliferator-Activated Receptors Alpha, Beta, and Gamma mRNA and Protein Expression in Human Fetal Tissues. PPAR Research،Vol. 2010, no. 2010, pp.1-19.
https://search.emarefa.net/detail/BIM-490867

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Abbott, Barbara D.…[et al.]. Peroxisome Proliferator-Activated Receptors Alpha, Beta, and Gamma mRNA and Protein Expression in Human Fetal Tissues. PPAR Research No. 2010 (2010), pp.1-19.
https://search.emarefa.net/detail/BIM-490867

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Abbott, Barbara D.& Wood, Carmen R.& Watkins, Andrew M.& Das, Kaberi P.& Lau, Christopher S.. Peroxisome Proliferator-Activated Receptors Alpha, Beta, and Gamma mRNA and Protein Expression in Human Fetal Tissues. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-19.
https://search.emarefa.net/detail/BIM-490867

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-490867