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Peroxisome Proliferator-Activated Receptors Alpha, Beta, and Gamma mRNA and Protein Expression in Human Fetal Tissues
Joint Authors
Watkins, Andrew M.
Das, Kaberi P.
Wood, Carmen R.
Abbott, Barbara D.
Lau, Christopher S.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-26
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptors (PPARs) regulate lipid and glucose homeostasis, are targets of pharmaceuticals, and are also activated by environmental contaminants.
Almost nothing is known about expression of PPARs during human fetal development.
This study examines expression of PPARα, β, and γ mRNA and protein in human fetal tissues.
With increasing fetal age, mRNA expression of PPARα and β increased in liver, but PPARβ decreased in heart and intestine, and PPARγ decreased in adrenal.
Adult and fetal mean expression of PPARα, β, and γ mRNA did not differ in intestine, but expression was lower in fetal stomach and heart.
PPARα and β mRNA in kidney and spleen, and PPARγ mRNA in lung and adrenal were lower in fetal versus adult.
PPARγ in liver and PPARβ mRNA in thymus were higher in fetal versus adult.
PPARα protein increased with fetal age in intestine and decreased in lung, kidney, and adrenal.
PPARβ protein in adrenal and PPARγ in kidney decreased with fetal age.
This study provides new information on expression of PPAR subtypes during human development and will be important in evaluating the potential for the developing human to respond to PPAR environmental or pharmaceutical agonists.Erratum to “Peroxisome Proliferator-Activated Receptors Alpha, Beta, and Gamma mRNA and Protein Expression in Human Fetal Tissues”dx.doi.org/10.1155/2010/627284
American Psychological Association (APA)
Abbott, Barbara D.& Wood, Carmen R.& Watkins, Andrew M.& Das, Kaberi P.& Lau, Christopher S.. 2010. Peroxisome Proliferator-Activated Receptors Alpha, Beta, and Gamma mRNA and Protein Expression in Human Fetal Tissues. PPAR Research،Vol. 2010, no. 2010, pp.1-19.
https://search.emarefa.net/detail/BIM-490867
Modern Language Association (MLA)
Abbott, Barbara D.…[et al.]. Peroxisome Proliferator-Activated Receptors Alpha, Beta, and Gamma mRNA and Protein Expression in Human Fetal Tissues. PPAR Research No. 2010 (2010), pp.1-19.
https://search.emarefa.net/detail/BIM-490867
American Medical Association (AMA)
Abbott, Barbara D.& Wood, Carmen R.& Watkins, Andrew M.& Das, Kaberi P.& Lau, Christopher S.. Peroxisome Proliferator-Activated Receptors Alpha, Beta, and Gamma mRNA and Protein Expression in Human Fetal Tissues. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-19.
https://search.emarefa.net/detail/BIM-490867
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490867