Synthesis, Characterization, and In Vitro Cytotoxic Activities of Benzaldehyde Thiosemicarbazone Derivatives and Their Palladium(II) and Platinum(II) Complexes against Various Human Tumor Cell Lines
المؤلفون المشاركون
Vaisberg, Abraham
Spodine, Evgenia
Richter, Rainer
Hernández, Wilfredo
Beyer, Lothar
Paz, Juan
المصدر
Bioinorganic Chemistry and Applications
العدد
المجلد 2008، العدد 2008 (31 ديسمبر/كانون الأول 2008)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-01-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The palladium(II) bis-chelate Pd (L1−3)2 and platinum(II) tetranuclear Pt4(L4)4 complexes of benzaldehyde thiosemicarbazone derivatives have been synthesized, and characterized by elemental analysis and IR, FAB(+)-mass and NMR (1H,13C) spectroscopy.
The complex Pd(L2)2 [HL2=m-CN-benzaldehyde thiosemicarbazone] shows a square-planar geometry with two deprotonated ligands (L) coordinated to PdII through the nitrogen and sulphur atoms in a trans arrangement, while the complex Pt4(L4)4 [HL4=4-phenyl-1-benzaldehyde thiosemicarbazone] has a tetranuclear geometry with four tridentate ligands coordinated to four PtII ions through the carbon (aromatic ring), nitrogen, and sulphur atoms where the ligands are deprotonated at the NH group.
The in vitro antitumor activity of the ligands and their complexes was determined against different human tumor cell lines, which revealed that the palladium(II) and platinum(II) complexes are more cytotoxic than their ligands with IC50 values at the range of 0.07–3.67 μM.
The tetranuclear complex Pt4(L4)4, with the phenyl group in the terminal amine of the ligand, showed higher antiproliferative activity (CI50 = 0.07–0.12 μM) than the other tested palladium(II) complexes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hernández, Wilfredo& Paz, Juan& Vaisberg, Abraham& Spodine, Evgenia& Richter, Rainer& Beyer, Lothar. 2009. Synthesis, Characterization, and In Vitro Cytotoxic Activities of Benzaldehyde Thiosemicarbazone Derivatives and Their Palladium(II) and Platinum(II) Complexes against Various Human Tumor Cell Lines. Bioinorganic Chemistry and Applications،Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-490873
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hernández, Wilfredo…[et al.]. Synthesis, Characterization, and In Vitro Cytotoxic Activities of Benzaldehyde Thiosemicarbazone Derivatives and Their Palladium(II) and Platinum(II) Complexes against Various Human Tumor Cell Lines. Bioinorganic Chemistry and Applications No. 2008 (2008), pp.1-9.
https://search.emarefa.net/detail/BIM-490873
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hernández, Wilfredo& Paz, Juan& Vaisberg, Abraham& Spodine, Evgenia& Richter, Rainer& Beyer, Lothar. Synthesis, Characterization, and In Vitro Cytotoxic Activities of Benzaldehyde Thiosemicarbazone Derivatives and Their Palladium(II) and Platinum(II) Complexes against Various Human Tumor Cell Lines. Bioinorganic Chemistry and Applications. 2009. Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-490873
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490873
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر