Synthesis, Characterization, and In Vitro Cytotoxic Activities of Benzaldehyde Thiosemicarbazone Derivatives and Their Palladium(II) and Platinum(II) Complexes against Various Human Tumor Cell Lines
Joint Authors
Vaisberg, Abraham
Spodine, Evgenia
Richter, Rainer
Hernández, Wilfredo
Beyer, Lothar
Paz, Juan
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-01-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The palladium(II) bis-chelate Pd (L1−3)2 and platinum(II) tetranuclear Pt4(L4)4 complexes of benzaldehyde thiosemicarbazone derivatives have been synthesized, and characterized by elemental analysis and IR, FAB(+)-mass and NMR (1H,13C) spectroscopy.
The complex Pd(L2)2 [HL2=m-CN-benzaldehyde thiosemicarbazone] shows a square-planar geometry with two deprotonated ligands (L) coordinated to PdII through the nitrogen and sulphur atoms in a trans arrangement, while the complex Pt4(L4)4 [HL4=4-phenyl-1-benzaldehyde thiosemicarbazone] has a tetranuclear geometry with four tridentate ligands coordinated to four PtII ions through the carbon (aromatic ring), nitrogen, and sulphur atoms where the ligands are deprotonated at the NH group.
The in vitro antitumor activity of the ligands and their complexes was determined against different human tumor cell lines, which revealed that the palladium(II) and platinum(II) complexes are more cytotoxic than their ligands with IC50 values at the range of 0.07–3.67 μM.
The tetranuclear complex Pt4(L4)4, with the phenyl group in the terminal amine of the ligand, showed higher antiproliferative activity (CI50 = 0.07–0.12 μM) than the other tested palladium(II) complexes.
American Psychological Association (APA)
Hernández, Wilfredo& Paz, Juan& Vaisberg, Abraham& Spodine, Evgenia& Richter, Rainer& Beyer, Lothar. 2009. Synthesis, Characterization, and In Vitro Cytotoxic Activities of Benzaldehyde Thiosemicarbazone Derivatives and Their Palladium(II) and Platinum(II) Complexes against Various Human Tumor Cell Lines. Bioinorganic Chemistry and Applications،Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-490873
Modern Language Association (MLA)
Hernández, Wilfredo…[et al.]. Synthesis, Characterization, and In Vitro Cytotoxic Activities of Benzaldehyde Thiosemicarbazone Derivatives and Their Palladium(II) and Platinum(II) Complexes against Various Human Tumor Cell Lines. Bioinorganic Chemistry and Applications No. 2008 (2008), pp.1-9.
https://search.emarefa.net/detail/BIM-490873
American Medical Association (AMA)
Hernández, Wilfredo& Paz, Juan& Vaisberg, Abraham& Spodine, Evgenia& Richter, Rainer& Beyer, Lothar. Synthesis, Characterization, and In Vitro Cytotoxic Activities of Benzaldehyde Thiosemicarbazone Derivatives and Their Palladium(II) and Platinum(II) Complexes against Various Human Tumor Cell Lines. Bioinorganic Chemistry and Applications. 2009. Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-490873
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490873