Management of Coagulopathy in Patients with Decompensated Liver Cirrhosis
المؤلفون المشاركون
Amarapurkar, Deepak N.
Amarapurkar, Pooja D.
المصدر
International Journal of Hepatology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-11-17
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Patients with decompensated liver cirrhosis have significantly impaired synthetic function.
Many proteins involved in the coagulation process are synthesized in the liver.
Routinely performed tests of the coagulation are abnormal in patients with decompensated liver cirrhosis.
This has led to the widespread belief that decompensated liver cirrhosis is prototype of acquired hemorrhagic coagulopathy.
If prothrombin time is prolonged more than 3 seconds over control, invasive procedures like liver biopsy, splenoportogram, percutaneous cholangiography, or surgery were associated with increased risk of bleeding, and coagulopathy should be corrected with infusion of fresh frozen plasma.
These practices were without any scientific evidence and were associated with significant hazards of fresh frozen plasma transfusion.
Now, it is realized that coagulation is a complex process involving the interaction of procoagulation and anticoagulation factors and the fibrinolytic system.
As there is reduction in both anti and procoagulant factors, global tests of coagulation are normal in patients with acute and chronic liver disease indicating that coagulopathy in liver disease is more of a myth than a reality.
In the last few years, surgical techniques have substantially improved, and complex procedures like liver transplantation can be done without the use of blood or blood products.
Patients with liver cirrhosis may also be at increased risk of thrombosis.
In this paper, we will discuss coagulopathy, increased risk of thrombosis, and their management in decompensated liver cirrhosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Amarapurkar, Pooja D.& Amarapurkar, Deepak N.. 2011. Management of Coagulopathy in Patients with Decompensated Liver Cirrhosis. International Journal of Hepatology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-491275
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Amarapurkar, Pooja D.& Amarapurkar, Deepak N.. Management of Coagulopathy in Patients with Decompensated Liver Cirrhosis. International Journal of Hepatology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-491275
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Amarapurkar, Pooja D.& Amarapurkar, Deepak N.. Management of Coagulopathy in Patients with Decompensated Liver Cirrhosis. International Journal of Hepatology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-491275
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491275
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر