Management of Coagulopathy in Patients with Decompensated Liver Cirrhosis
Joint Authors
Amarapurkar, Deepak N.
Amarapurkar, Pooja D.
Source
International Journal of Hepatology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Patients with decompensated liver cirrhosis have significantly impaired synthetic function.
Many proteins involved in the coagulation process are synthesized in the liver.
Routinely performed tests of the coagulation are abnormal in patients with decompensated liver cirrhosis.
This has led to the widespread belief that decompensated liver cirrhosis is prototype of acquired hemorrhagic coagulopathy.
If prothrombin time is prolonged more than 3 seconds over control, invasive procedures like liver biopsy, splenoportogram, percutaneous cholangiography, or surgery were associated with increased risk of bleeding, and coagulopathy should be corrected with infusion of fresh frozen plasma.
These practices were without any scientific evidence and were associated with significant hazards of fresh frozen plasma transfusion.
Now, it is realized that coagulation is a complex process involving the interaction of procoagulation and anticoagulation factors and the fibrinolytic system.
As there is reduction in both anti and procoagulant factors, global tests of coagulation are normal in patients with acute and chronic liver disease indicating that coagulopathy in liver disease is more of a myth than a reality.
In the last few years, surgical techniques have substantially improved, and complex procedures like liver transplantation can be done without the use of blood or blood products.
Patients with liver cirrhosis may also be at increased risk of thrombosis.
In this paper, we will discuss coagulopathy, increased risk of thrombosis, and their management in decompensated liver cirrhosis.
American Psychological Association (APA)
Amarapurkar, Pooja D.& Amarapurkar, Deepak N.. 2011. Management of Coagulopathy in Patients with Decompensated Liver Cirrhosis. International Journal of Hepatology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-491275
Modern Language Association (MLA)
Amarapurkar, Pooja D.& Amarapurkar, Deepak N.. Management of Coagulopathy in Patients with Decompensated Liver Cirrhosis. International Journal of Hepatology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-491275
American Medical Association (AMA)
Amarapurkar, Pooja D.& Amarapurkar, Deepak N.. Management of Coagulopathy in Patients with Decompensated Liver Cirrhosis. International Journal of Hepatology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-491275
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491275