Management of Coagulopathy in Patients with Decompensated Liver Cirrhosis

Joint Authors

Amarapurkar, Deepak N.
Amarapurkar, Pooja D.

Source

International Journal of Hepatology

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-11-17

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Medicine

Abstract EN

Patients with decompensated liver cirrhosis have significantly impaired synthetic function.

Many proteins involved in the coagulation process are synthesized in the liver.

Routinely performed tests of the coagulation are abnormal in patients with decompensated liver cirrhosis.

This has led to the widespread belief that decompensated liver cirrhosis is prototype of acquired hemorrhagic coagulopathy.

If prothrombin time is prolonged more than 3 seconds over control, invasive procedures like liver biopsy, splenoportogram, percutaneous cholangiography, or surgery were associated with increased risk of bleeding, and coagulopathy should be corrected with infusion of fresh frozen plasma.

These practices were without any scientific evidence and were associated with significant hazards of fresh frozen plasma transfusion.

Now, it is realized that coagulation is a complex process involving the interaction of procoagulation and anticoagulation factors and the fibrinolytic system.

As there is reduction in both anti and procoagulant factors, global tests of coagulation are normal in patients with acute and chronic liver disease indicating that coagulopathy in liver disease is more of a myth than a reality.

In the last few years, surgical techniques have substantially improved, and complex procedures like liver transplantation can be done without the use of blood or blood products.

Patients with liver cirrhosis may also be at increased risk of thrombosis.

In this paper, we will discuss coagulopathy, increased risk of thrombosis, and their management in decompensated liver cirrhosis.

American Psychological Association (APA)

Amarapurkar, Pooja D.& Amarapurkar, Deepak N.. 2011. Management of Coagulopathy in Patients with Decompensated Liver Cirrhosis. International Journal of Hepatology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-491275

Modern Language Association (MLA)

Amarapurkar, Pooja D.& Amarapurkar, Deepak N.. Management of Coagulopathy in Patients with Decompensated Liver Cirrhosis. International Journal of Hepatology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-491275

American Medical Association (AMA)

Amarapurkar, Pooja D.& Amarapurkar, Deepak N.. Management of Coagulopathy in Patients with Decompensated Liver Cirrhosis. International Journal of Hepatology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-491275

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-491275