Identification of Differentially Expressed Serum Proteins in Infectious Purpura Fulminans
المؤلفون المشاركون
Zhang, Dong-xia
Jiang, Xu-pin
Hu, Jiong-yu
Huang, Yue-sheng
Chen, Bing
He, Ting
Han, Jian
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-10
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpura fulminans (PF) is a life-threatening hemorrhagic condition.
Because of the rarity and randomness of the disease, no improvement in treatment has been made for a long time.
In this study, we assessed the serum proteome response to PF by comparing serum proteins between healthy controls and PF patient.
Liquid chromatography with tandem mass spectrometry (LC-MS/MS) approach was used after depleting 6 abundant proteins of serum.
In total, 262 proteins were confidently identified with 2 unique peptides, and 38 proteins were identified significantly up- (≥2) or downregulated (≤0.5) based on spectral counting ratios (SpCPF/N).
In the 38 proteins with significant abundance changes, 11 proteins were previously known to be associated with burn or sepsis response, but 27 potentially novel proteins may be specifically associated with PF process.
Two differentially expressed proteins, alpha-1-antitrypsin (SERPINA1) and alpha-2 antiplasmin (SERPINF2), were validated by Western blot.
This is the first study where PF patient and healthy controls are compared in a proteomic study to elucidate proteins involved in the response to PF.
This study provides an initial basis for future studies of PF, and the differentially expressed proteins might provide new therapeutic targets to decrease the mortality of PF.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
He, Ting& Hu, Jiong-yu& Han, Jian& Zhang, Dong-xia& Jiang, Xu-pin& Chen, Bing…[et al.]. 2014. Identification of Differentially Expressed Serum Proteins in Infectious Purpura Fulminans. Disease Markers،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-491530
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
He, Ting…[et al.]. Identification of Differentially Expressed Serum Proteins in Infectious Purpura Fulminans. Disease Markers No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-491530
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
He, Ting& Hu, Jiong-yu& Han, Jian& Zhang, Dong-xia& Jiang, Xu-pin& Chen, Bing…[et al.]. Identification of Differentially Expressed Serum Proteins in Infectious Purpura Fulminans. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-491530
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491530
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر