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Identification of Differentially Expressed Serum Proteins in Infectious Purpura Fulminans
Joint Authors
Zhang, Dong-xia
Jiang, Xu-pin
Hu, Jiong-yu
Huang, Yue-sheng
Chen, Bing
He, Ting
Han, Jian
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpura fulminans (PF) is a life-threatening hemorrhagic condition.
Because of the rarity and randomness of the disease, no improvement in treatment has been made for a long time.
In this study, we assessed the serum proteome response to PF by comparing serum proteins between healthy controls and PF patient.
Liquid chromatography with tandem mass spectrometry (LC-MS/MS) approach was used after depleting 6 abundant proteins of serum.
In total, 262 proteins were confidently identified with 2 unique peptides, and 38 proteins were identified significantly up- (≥2) or downregulated (≤0.5) based on spectral counting ratios (SpCPF/N).
In the 38 proteins with significant abundance changes, 11 proteins were previously known to be associated with burn or sepsis response, but 27 potentially novel proteins may be specifically associated with PF process.
Two differentially expressed proteins, alpha-1-antitrypsin (SERPINA1) and alpha-2 antiplasmin (SERPINF2), were validated by Western blot.
This is the first study where PF patient and healthy controls are compared in a proteomic study to elucidate proteins involved in the response to PF.
This study provides an initial basis for future studies of PF, and the differentially expressed proteins might provide new therapeutic targets to decrease the mortality of PF.
American Psychological Association (APA)
He, Ting& Hu, Jiong-yu& Han, Jian& Zhang, Dong-xia& Jiang, Xu-pin& Chen, Bing…[et al.]. 2014. Identification of Differentially Expressed Serum Proteins in Infectious Purpura Fulminans. Disease Markers،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-491530
Modern Language Association (MLA)
He, Ting…[et al.]. Identification of Differentially Expressed Serum Proteins in Infectious Purpura Fulminans. Disease Markers No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-491530
American Medical Association (AMA)
He, Ting& Hu, Jiong-yu& Han, Jian& Zhang, Dong-xia& Jiang, Xu-pin& Chen, Bing…[et al.]. Identification of Differentially Expressed Serum Proteins in Infectious Purpura Fulminans. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-491530
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491530