Alterations of Hormone-Sensitive Adenylyl Cyclase System in the Tissues of Rats with Long-Term Streptozotocin Diabetes and the Influence of Intranasal Insulin
المؤلفون المشاركون
Derkach, Kira V.
Shpakov, Alexander O.
Chistyakova, Oksana V.
Moyseyuk, Irina V.
المصدر
Dataset Papers in Pharmacology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-27
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
One of the causes of complications in type 1 diabetes mellitus (T1DM) is the changes in adenylyl cyclase (AC) signaling system, identified on the early stages of the disease.
However, the most significant disturbances in this system occur on the later stages of T1DM, which ultimately leads to severe complications, but functional state of the AC system in late T1DM is poorly understood.
The aim of this work was to study alterations in AC system sensitive to biogenic amines and polypeptide hormones in the heart, brain, and testes of male rats with long-term, 7-month, streptozotocin T1DM and to assess the influence on them of 135-day therapy with intranasal insulin.
It was shown that AC effects of β-adrenergic agonists in the heart, serotonin receptor agonists and PACAP-38 in the brain, chorionic gonadotropin and PACAP-38 in the testes, and somatostatin in all investigated tissues in long-term T1DM were drastically decreased.
The treatment with intranasal insulin (0.48 IU/day) significantly restored these effects.
The results were obtained suggesting that long-term T1DM induces significant alterations in hormone-sensitive AC system in the heart, brain, and testes that are much more pronounced, compared with short-term T1DM, and include a large number of hormonal regulations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shpakov, Alexander O.& Derkach, Kira V.& Moyseyuk, Irina V.& Chistyakova, Oksana V.. 2012. Alterations of Hormone-Sensitive Adenylyl Cyclase System in the Tissues of Rats with Long-Term Streptozotocin Diabetes and the Influence of Intranasal Insulin. Dataset Papers in Pharmacology،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-491538
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shpakov, Alexander O.…[et al.]. Alterations of Hormone-Sensitive Adenylyl Cyclase System in the Tissues of Rats with Long-Term Streptozotocin Diabetes and the Influence of Intranasal Insulin. Dataset Papers in Pharmacology No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-491538
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shpakov, Alexander O.& Derkach, Kira V.& Moyseyuk, Irina V.& Chistyakova, Oksana V.. Alterations of Hormone-Sensitive Adenylyl Cyclase System in the Tissues of Rats with Long-Term Streptozotocin Diabetes and the Influence of Intranasal Insulin. Dataset Papers in Pharmacology. 2012. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-491538
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491538
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر