Alterations of Hormone-Sensitive Adenylyl Cyclase System in the Tissues of Rats with Long-Term Streptozotocin Diabetes and the Influence of Intranasal Insulin
Joint Authors
Derkach, Kira V.
Shpakov, Alexander O.
Chistyakova, Oksana V.
Moyseyuk, Irina V.
Source
Dataset Papers in Pharmacology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-27
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
One of the causes of complications in type 1 diabetes mellitus (T1DM) is the changes in adenylyl cyclase (AC) signaling system, identified on the early stages of the disease.
However, the most significant disturbances in this system occur on the later stages of T1DM, which ultimately leads to severe complications, but functional state of the AC system in late T1DM is poorly understood.
The aim of this work was to study alterations in AC system sensitive to biogenic amines and polypeptide hormones in the heart, brain, and testes of male rats with long-term, 7-month, streptozotocin T1DM and to assess the influence on them of 135-day therapy with intranasal insulin.
It was shown that AC effects of β-adrenergic agonists in the heart, serotonin receptor agonists and PACAP-38 in the brain, chorionic gonadotropin and PACAP-38 in the testes, and somatostatin in all investigated tissues in long-term T1DM were drastically decreased.
The treatment with intranasal insulin (0.48 IU/day) significantly restored these effects.
The results were obtained suggesting that long-term T1DM induces significant alterations in hormone-sensitive AC system in the heart, brain, and testes that are much more pronounced, compared with short-term T1DM, and include a large number of hormonal regulations.
American Psychological Association (APA)
Shpakov, Alexander O.& Derkach, Kira V.& Moyseyuk, Irina V.& Chistyakova, Oksana V.. 2012. Alterations of Hormone-Sensitive Adenylyl Cyclase System in the Tissues of Rats with Long-Term Streptozotocin Diabetes and the Influence of Intranasal Insulin. Dataset Papers in Pharmacology،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-491538
Modern Language Association (MLA)
Shpakov, Alexander O.…[et al.]. Alterations of Hormone-Sensitive Adenylyl Cyclase System in the Tissues of Rats with Long-Term Streptozotocin Diabetes and the Influence of Intranasal Insulin. Dataset Papers in Pharmacology No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-491538
American Medical Association (AMA)
Shpakov, Alexander O.& Derkach, Kira V.& Moyseyuk, Irina V.& Chistyakova, Oksana V.. Alterations of Hormone-Sensitive Adenylyl Cyclase System in the Tissues of Rats with Long-Term Streptozotocin Diabetes and the Influence of Intranasal Insulin. Dataset Papers in Pharmacology. 2012. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-491538
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491538