Neurogenesis, Exercise, and Cognitive Late Effects of Pediatric Radiotherapy
المؤلفون المشاركون
Leasure, J. Leigh
Zawaski, Janice A.
Trevino, Melissa
Rodgers, Shaefali P.
Gaber, M. Waleed
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-14
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Brain cancer is a common type of childhood malignancy, and radiotherapy (RT) is a mainstay of treatment.
RT is effective for tumor eradication, and survival rates are high.
However, RT damages the brain and disrupts ongoing developmental processes, resulting in debilitating cognitive “late” effects that may take years to fully manifest.
These late effects likely derive from a long-term decrement in cell proliferation, combined with a neural environment that is hostile to plasticity, both of which are induced by RT.
Long-term suppression of cell proliferation deprives the brain of the raw materials needed for optimum cognitive performance (such as new neurons in the hippocampus and new glia in frontal cortex), while chronic inflammation and dearth of trophic substances (such as growth hormone) limit neuroplastic potential in existing circuitry.
Potential treatments for cognitive late effects should address both of these conditions.
Exercise represents one such potential treatment, since it has the capacity to enhance cell proliferation, as well as to promote a neural milieu permissive for plasticity.
Here, we review the evidence that cognitive late effects can be traced to RT-induced suppression of cell proliferation and hostile environmental conditions, as well as emerging evidence that exercise may be effective as an independent or adjuvant therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rodgers, Shaefali P.& Trevino, Melissa& Zawaski, Janice A.& Gaber, M. Waleed& Leasure, J. Leigh. 2013. Neurogenesis, Exercise, and Cognitive Late Effects of Pediatric Radiotherapy. Neural Plasticity،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-491547
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rodgers, Shaefali P.…[et al.]. Neurogenesis, Exercise, and Cognitive Late Effects of Pediatric Radiotherapy. Neural Plasticity No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-491547
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rodgers, Shaefali P.& Trevino, Melissa& Zawaski, Janice A.& Gaber, M. Waleed& Leasure, J. Leigh. Neurogenesis, Exercise, and Cognitive Late Effects of Pediatric Radiotherapy. Neural Plasticity. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-491547
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491547
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر