Neurogenesis, Exercise, and Cognitive Late Effects of Pediatric Radiotherapy
Joint Authors
Leasure, J. Leigh
Zawaski, Janice A.
Trevino, Melissa
Rodgers, Shaefali P.
Gaber, M. Waleed
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Brain cancer is a common type of childhood malignancy, and radiotherapy (RT) is a mainstay of treatment.
RT is effective for tumor eradication, and survival rates are high.
However, RT damages the brain and disrupts ongoing developmental processes, resulting in debilitating cognitive “late” effects that may take years to fully manifest.
These late effects likely derive from a long-term decrement in cell proliferation, combined with a neural environment that is hostile to plasticity, both of which are induced by RT.
Long-term suppression of cell proliferation deprives the brain of the raw materials needed for optimum cognitive performance (such as new neurons in the hippocampus and new glia in frontal cortex), while chronic inflammation and dearth of trophic substances (such as growth hormone) limit neuroplastic potential in existing circuitry.
Potential treatments for cognitive late effects should address both of these conditions.
Exercise represents one such potential treatment, since it has the capacity to enhance cell proliferation, as well as to promote a neural milieu permissive for plasticity.
Here, we review the evidence that cognitive late effects can be traced to RT-induced suppression of cell proliferation and hostile environmental conditions, as well as emerging evidence that exercise may be effective as an independent or adjuvant therapy.
American Psychological Association (APA)
Rodgers, Shaefali P.& Trevino, Melissa& Zawaski, Janice A.& Gaber, M. Waleed& Leasure, J. Leigh. 2013. Neurogenesis, Exercise, and Cognitive Late Effects of Pediatric Radiotherapy. Neural Plasticity،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-491547
Modern Language Association (MLA)
Rodgers, Shaefali P.…[et al.]. Neurogenesis, Exercise, and Cognitive Late Effects of Pediatric Radiotherapy. Neural Plasticity No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-491547
American Medical Association (AMA)
Rodgers, Shaefali P.& Trevino, Melissa& Zawaski, Janice A.& Gaber, M. Waleed& Leasure, J. Leigh. Neurogenesis, Exercise, and Cognitive Late Effects of Pediatric Radiotherapy. Neural Plasticity. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-491547
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491547