Dementia and Diabetes Mellitus : Association with Apolipoprotein E4 Polymorphism from a Hospital in Southern India
المؤلفون المشاركون
Krishnappa, Srinivas Brahmadevarahalli
Sadanand, Shilpa
Shankarappa, Bhagyalakshmi Mallapura
Jain, Sanjeev
Shivakumar, Prafulla
Bagepally, Bhavani Shankara
Purushottam, Meera
Bharath, Srikala
Varghese, Mathew
Kota, Lakshmi Narayanan
Sivakumar, Palanimuthu Thangaraju
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-03
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Objective.
To evaluate the association of Apolipoprotein E4 (ApoE4) in Alzheimer's dementia (AD) with comorbid diabetes mellitus (DM).
Methods.
The study included subjects with Alzheimer's dementia (AD) (n=209), individuals with non-Alzheimer's dementia (nAD) (n=122), individuals with parental history of AD (f/hAD) (n=70), and control individuals who had normal cognitive functions and no parental history of dementia (NC) (n=193).
Dementia was diagnosed using International Classification of Diseases-10 revision (ICD-10) criteria.
DM was assessed on the basis of self-report and/or use of antidiabetic medications.
ApoE genotyping was done using sequence-specific primer polymerase chain reaction.
Results.
ApoE4 allele frequencies were highest among AD with comorbid DM (0.35) followed by AD without DM (0.25), nAD with DM (0.13), nAD without comorbid DM (0.12), and NC (0.08).
Frequency of ApoE4 in persons with f/hAD was 0.13.
The association of AD with co-morbid DM in ApoE4 carriers was more in comparison to NC with DM (OR=5.68, P=0.04).
Conclusion.
There is a significant association between AD with co-morbid DM and ApoE4 genotype.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kota, Lakshmi Narayanan& Shankarappa, Bhagyalakshmi Mallapura& Shivakumar, Prafulla& Sadanand, Shilpa& Bagepally, Bhavani Shankara& Krishnappa, Srinivas Brahmadevarahalli…[et al.]. 2012. Dementia and Diabetes Mellitus : Association with Apolipoprotein E4 Polymorphism from a Hospital in Southern India. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-491779
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kota, Lakshmi Narayanan…[et al.]. Dementia and Diabetes Mellitus : Association with Apolipoprotein E4 Polymorphism from a Hospital in Southern India. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-491779
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kota, Lakshmi Narayanan& Shankarappa, Bhagyalakshmi Mallapura& Shivakumar, Prafulla& Sadanand, Shilpa& Bagepally, Bhavani Shankara& Krishnappa, Srinivas Brahmadevarahalli…[et al.]. Dementia and Diabetes Mellitus : Association with Apolipoprotein E4 Polymorphism from a Hospital in Southern India. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-491779
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491779
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر