Dementia and Diabetes Mellitus : Association with Apolipoprotein E4 Polymorphism from a Hospital in Southern India

Joint Authors

Krishnappa, Srinivas Brahmadevarahalli
Sadanand, Shilpa
Shankarappa, Bhagyalakshmi Mallapura
Jain, Sanjeev
Shivakumar, Prafulla
Bagepally, Bhavani Shankara
Purushottam, Meera
Bharath, Srikala
Varghese, Mathew
Kota, Lakshmi Narayanan
Sivakumar, Palanimuthu Thangaraju

Source

International Journal of Alzheimer's Disease

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-06-03

Country of Publication

Egypt

No. of Pages

4

Main Subjects

Diseases
Medicine

Abstract EN

Objective.

To evaluate the association of Apolipoprotein E4 (ApoE4) in Alzheimer's dementia (AD) with comorbid diabetes mellitus (DM).

Methods.

The study included subjects with Alzheimer's dementia (AD) (n=209), individuals with non-Alzheimer's dementia (nAD) (n=122), individuals with parental history of AD (f/hAD) (n=70), and control individuals who had normal cognitive functions and no parental history of dementia (NC) (n=193).

Dementia was diagnosed using International Classification of Diseases-10 revision (ICD-10) criteria.

DM was assessed on the basis of self-report and/or use of antidiabetic medications.

ApoE genotyping was done using sequence-specific primer polymerase chain reaction.

Results.

ApoE4 allele frequencies were highest among AD with comorbid DM (0.35) followed by AD without DM (0.25), nAD with DM (0.13), nAD without comorbid DM (0.12), and NC (0.08).

Frequency of ApoE4 in persons with f/hAD was 0.13.

The association of AD with co-morbid DM in ApoE4 carriers was more in comparison to NC with DM (OR=5.68, P=0.04).

Conclusion.

There is a significant association between AD with co-morbid DM and ApoE4 genotype.

American Psychological Association (APA)

Kota, Lakshmi Narayanan& Shankarappa, Bhagyalakshmi Mallapura& Shivakumar, Prafulla& Sadanand, Shilpa& Bagepally, Bhavani Shankara& Krishnappa, Srinivas Brahmadevarahalli…[et al.]. 2012. Dementia and Diabetes Mellitus : Association with Apolipoprotein E4 Polymorphism from a Hospital in Southern India. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-491779

Modern Language Association (MLA)

Kota, Lakshmi Narayanan…[et al.]. Dementia and Diabetes Mellitus : Association with Apolipoprotein E4 Polymorphism from a Hospital in Southern India. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-491779

American Medical Association (AMA)

Kota, Lakshmi Narayanan& Shankarappa, Bhagyalakshmi Mallapura& Shivakumar, Prafulla& Sadanand, Shilpa& Bagepally, Bhavani Shankara& Krishnappa, Srinivas Brahmadevarahalli…[et al.]. Dementia and Diabetes Mellitus : Association with Apolipoprotein E4 Polymorphism from a Hospital in Southern India. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-491779

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-491779