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Dementia and Diabetes Mellitus : Association with Apolipoprotein E4 Polymorphism from a Hospital in Southern India
Joint Authors
Krishnappa, Srinivas Brahmadevarahalli
Sadanand, Shilpa
Shankarappa, Bhagyalakshmi Mallapura
Jain, Sanjeev
Shivakumar, Prafulla
Bagepally, Bhavani Shankara
Purushottam, Meera
Bharath, Srikala
Varghese, Mathew
Kota, Lakshmi Narayanan
Sivakumar, Palanimuthu Thangaraju
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-03
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Objective.
To evaluate the association of Apolipoprotein E4 (ApoE4) in Alzheimer's dementia (AD) with comorbid diabetes mellitus (DM).
Methods.
The study included subjects with Alzheimer's dementia (AD) (n=209), individuals with non-Alzheimer's dementia (nAD) (n=122), individuals with parental history of AD (f/hAD) (n=70), and control individuals who had normal cognitive functions and no parental history of dementia (NC) (n=193).
Dementia was diagnosed using International Classification of Diseases-10 revision (ICD-10) criteria.
DM was assessed on the basis of self-report and/or use of antidiabetic medications.
ApoE genotyping was done using sequence-specific primer polymerase chain reaction.
Results.
ApoE4 allele frequencies were highest among AD with comorbid DM (0.35) followed by AD without DM (0.25), nAD with DM (0.13), nAD without comorbid DM (0.12), and NC (0.08).
Frequency of ApoE4 in persons with f/hAD was 0.13.
The association of AD with co-morbid DM in ApoE4 carriers was more in comparison to NC with DM (OR=5.68, P=0.04).
Conclusion.
There is a significant association between AD with co-morbid DM and ApoE4 genotype.
American Psychological Association (APA)
Kota, Lakshmi Narayanan& Shankarappa, Bhagyalakshmi Mallapura& Shivakumar, Prafulla& Sadanand, Shilpa& Bagepally, Bhavani Shankara& Krishnappa, Srinivas Brahmadevarahalli…[et al.]. 2012. Dementia and Diabetes Mellitus : Association with Apolipoprotein E4 Polymorphism from a Hospital in Southern India. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-491779
Modern Language Association (MLA)
Kota, Lakshmi Narayanan…[et al.]. Dementia and Diabetes Mellitus : Association with Apolipoprotein E4 Polymorphism from a Hospital in Southern India. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-491779
American Medical Association (AMA)
Kota, Lakshmi Narayanan& Shankarappa, Bhagyalakshmi Mallapura& Shivakumar, Prafulla& Sadanand, Shilpa& Bagepally, Bhavani Shankara& Krishnappa, Srinivas Brahmadevarahalli…[et al.]. Dementia and Diabetes Mellitus : Association with Apolipoprotein E4 Polymorphism from a Hospital in Southern India. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-491779
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491779