Oxytocin Improves Follicular Reserve in a Cisplatin-Induced Gonadotoxicity Model in Rats
المؤلفون المشاركون
Terek, Mustafa Cosan
Taskiran, Dilek
Yavaşoğlu, Altuğ
Erbaş, Oytun
Akman, Tülay
Akman, Levent
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-14
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Cisplatin (CP), an antitumor agent, has been shown to cause ovarian injury and dysfunction in both animal and human studies.
The present study was conducted to investigate the protective effect of oxytocin (OT) on CP-induced ovarian toxicity in rats.
Twenty-one adult female rats were included in the study.
Fourteen rats were administered intraperitoneally CP (2 mg/kg/day) twice a week for 5 weeks.
Control group (n=7) did not receive any treatment.
Following treatment, CP-received rats were randomly divided into two groups and treated with either saline (1 mL/kg/day, n=7) or OT (160 μg/kg/day, n=7) for 5 weeks.
Then, ovarian toxicity and effects of OT were evaluated by histomorphological and biochemical analysis.
Our findings revealed a significant reduction in the number of follicles at each grade in saline-treated group.
AMH level was significantly lower in saline group compared to control (P<0.0005).
OT treatment significantly attenuated CP toxicity in ovaries and increased AMH levels compared to saline group (P<0.005).
Also, administration of OT lessened lipid peroxidation and prevented glutathione depletion in CP-treated rats (P<0.05).
These results indicated that OT could lessen the CP-induced ovarian damage and improve follicular reserve by preventing oxidative damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Erbaş, Oytun& Akman, Levent& Yavaşoğlu, Altuğ& Terek, Mustafa Cosan& Akman, Tülay& Taskiran, Dilek. 2014. Oxytocin Improves Follicular Reserve in a Cisplatin-Induced Gonadotoxicity Model in Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-491842
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Erbaş, Oytun…[et al.]. Oxytocin Improves Follicular Reserve in a Cisplatin-Induced Gonadotoxicity Model in Rats. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-491842
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Erbaş, Oytun& Akman, Levent& Yavaşoğlu, Altuğ& Terek, Mustafa Cosan& Akman, Tülay& Taskiran, Dilek. Oxytocin Improves Follicular Reserve in a Cisplatin-Induced Gonadotoxicity Model in Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-491842
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491842
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر