Oxytocin Improves Follicular Reserve in a Cisplatin-Induced Gonadotoxicity Model in Rats
Joint Authors
Terek, Mustafa Cosan
Taskiran, Dilek
Yavaşoğlu, Altuğ
Erbaş, Oytun
Akman, Tülay
Akman, Levent
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Cisplatin (CP), an antitumor agent, has been shown to cause ovarian injury and dysfunction in both animal and human studies.
The present study was conducted to investigate the protective effect of oxytocin (OT) on CP-induced ovarian toxicity in rats.
Twenty-one adult female rats were included in the study.
Fourteen rats were administered intraperitoneally CP (2 mg/kg/day) twice a week for 5 weeks.
Control group (n=7) did not receive any treatment.
Following treatment, CP-received rats were randomly divided into two groups and treated with either saline (1 mL/kg/day, n=7) or OT (160 μg/kg/day, n=7) for 5 weeks.
Then, ovarian toxicity and effects of OT were evaluated by histomorphological and biochemical analysis.
Our findings revealed a significant reduction in the number of follicles at each grade in saline-treated group.
AMH level was significantly lower in saline group compared to control (P<0.0005).
OT treatment significantly attenuated CP toxicity in ovaries and increased AMH levels compared to saline group (P<0.005).
Also, administration of OT lessened lipid peroxidation and prevented glutathione depletion in CP-treated rats (P<0.05).
These results indicated that OT could lessen the CP-induced ovarian damage and improve follicular reserve by preventing oxidative damage.
American Psychological Association (APA)
Erbaş, Oytun& Akman, Levent& Yavaşoğlu, Altuğ& Terek, Mustafa Cosan& Akman, Tülay& Taskiran, Dilek. 2014. Oxytocin Improves Follicular Reserve in a Cisplatin-Induced Gonadotoxicity Model in Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-491842
Modern Language Association (MLA)
Erbaş, Oytun…[et al.]. Oxytocin Improves Follicular Reserve in a Cisplatin-Induced Gonadotoxicity Model in Rats. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-491842
American Medical Association (AMA)
Erbaş, Oytun& Akman, Levent& Yavaşoğlu, Altuğ& Terek, Mustafa Cosan& Akman, Tülay& Taskiran, Dilek. Oxytocin Improves Follicular Reserve in a Cisplatin-Induced Gonadotoxicity Model in Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-491842
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491842