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TSH Isoforms : About a Case of Hypothyroidism in a Down's Syndrome Young Adult
المؤلفون المشاركون
Chikh, Karim
Ronin, Catherine
Gauchez, Anne-Sophie
Alcaraz-Galvain, Dany
Pizzo, Magali
Orgiazzi, Jacques
Brabant, Georg
Charrié, Anne
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-07-14
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
For unknown reasons, the prevalence of thyroid autoimmune disorders is higher in patients with Down's syndrome than in the general population.
The present case strongly supports a recent evaluation of propagating screening for thyroid disease in this group of patients to assure early diagnosis of hypothyroidism.
Methods.
In a 25-year-old man diagnosed with Down's syndrome, clinical manifestations of hypothyroidism were lacking, but profound biochemical abnormalities were found with particularly high levels of thyroid stimulating hormone (TSH).
Antigenic properties of TSH were characterized using a panel of anti-TSH antibodies.
Results.
Technical problems not infrequently associated with TSH measurements are convincingly ruled out.
Antigenic characterization of the patient's circulating TSH revealed circulating forms of TSH different from pituitary TSH which closely resembled TSH recombinant human hormone.
Conclusions.
It appears counterintuitive that the bioactivity of TSH decreases in the hypothyroid state as higher bioactivity of TSH is anticipated in hypothyroidism promoted by an increased hypothalamic TRH drive.
In contrast, diminished negative thyroid hormone feedback will enhance posttranslational glycosylation of TSH subunits and increase sialylation of the carbohydrate side chains.
Both exert a negative effect on TSH bioactivity, only compensated by the very high levels of the hormone as in the present case.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gauchez, Anne-Sophie& Pizzo, Magali& Alcaraz-Galvain, Dany& Chikh, Karim& Orgiazzi, Jacques& Brabant, Georg…[et al.]. 2010. TSH Isoforms : About a Case of Hypothyroidism in a Down's Syndrome Young Adult. Journal of Thyroid Research،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-491883
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gauchez, Anne-Sophie…[et al.]. TSH Isoforms : About a Case of Hypothyroidism in a Down's Syndrome Young Adult. Journal of Thyroid Research No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-491883
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gauchez, Anne-Sophie& Pizzo, Magali& Alcaraz-Galvain, Dany& Chikh, Karim& Orgiazzi, Jacques& Brabant, Georg…[et al.]. TSH Isoforms : About a Case of Hypothyroidism in a Down's Syndrome Young Adult. Journal of Thyroid Research. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-491883
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491883
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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