TSH Isoforms : About a Case of Hypothyroidism in a Down's Syndrome Young Adult
Joint Authors
Chikh, Karim
Ronin, Catherine
Gauchez, Anne-Sophie
Alcaraz-Galvain, Dany
Pizzo, Magali
Orgiazzi, Jacques
Brabant, Georg
Charrié, Anne
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
For unknown reasons, the prevalence of thyroid autoimmune disorders is higher in patients with Down's syndrome than in the general population.
The present case strongly supports a recent evaluation of propagating screening for thyroid disease in this group of patients to assure early diagnosis of hypothyroidism.
Methods.
In a 25-year-old man diagnosed with Down's syndrome, clinical manifestations of hypothyroidism were lacking, but profound biochemical abnormalities were found with particularly high levels of thyroid stimulating hormone (TSH).
Antigenic properties of TSH were characterized using a panel of anti-TSH antibodies.
Results.
Technical problems not infrequently associated with TSH measurements are convincingly ruled out.
Antigenic characterization of the patient's circulating TSH revealed circulating forms of TSH different from pituitary TSH which closely resembled TSH recombinant human hormone.
Conclusions.
It appears counterintuitive that the bioactivity of TSH decreases in the hypothyroid state as higher bioactivity of TSH is anticipated in hypothyroidism promoted by an increased hypothalamic TRH drive.
In contrast, diminished negative thyroid hormone feedback will enhance posttranslational glycosylation of TSH subunits and increase sialylation of the carbohydrate side chains.
Both exert a negative effect on TSH bioactivity, only compensated by the very high levels of the hormone as in the present case.
American Psychological Association (APA)
Gauchez, Anne-Sophie& Pizzo, Magali& Alcaraz-Galvain, Dany& Chikh, Karim& Orgiazzi, Jacques& Brabant, Georg…[et al.]. 2010. TSH Isoforms : About a Case of Hypothyroidism in a Down's Syndrome Young Adult. Journal of Thyroid Research،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-491883
Modern Language Association (MLA)
Gauchez, Anne-Sophie…[et al.]. TSH Isoforms : About a Case of Hypothyroidism in a Down's Syndrome Young Adult. Journal of Thyroid Research No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-491883
American Medical Association (AMA)
Gauchez, Anne-Sophie& Pizzo, Magali& Alcaraz-Galvain, Dany& Chikh, Karim& Orgiazzi, Jacques& Brabant, Georg…[et al.]. TSH Isoforms : About a Case of Hypothyroidism in a Down's Syndrome Young Adult. Journal of Thyroid Research. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-491883
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491883