![](/images/graphics-bg.png)
Prions Ex Vivo : What Cell Culture Models Tell Us about Infectious Proteins
المؤلفون المشاركون
المصدر
International Journal of Cell Biology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-26
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Prions are unconventional infectious agents that are composed of misfolded aggregated prion protein.
Prions replicate their conformation by template-assisted conversion of the endogenous prion protein PrP.
Templated conversion of soluble proteins into protein aggregates is also a hallmark of other neurodegenerative diseases.
Alzheimer’s disease or Parkinson’s disease are not considered infectious diseases, although aggregate pathology appears to progress in a stereotypical fashion reminiscent of the spreading behavior ofmammalian prions.
While basic principles of prion formation have been studied extensively, it is still unclear what exactly drives PrP molecules into an infectious, self-templating conformation.
In this review, we discuss crucial steps in the life cycle of prions that have been revealed in ex vivo models.
Importantly, the persistent propagation of prions in mitotically active cells argues that cellular processes are in place that not only allow recruitment of cellular PrP into growing prion aggregates but also enable the multiplication of infectious seeds that are transmitted to daughter cells.
Comparison of prions with other protein aggregates demonstrates that not all the characteristics of prions are equally shared by prion-like aggregates.
Future experiments may reveal to which extent aggregation-prone proteins associated with other neurodegenerative diseases can copy the replication strategies of prions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Krauss, Sybille& Vorberg, Ina. 2013. Prions Ex Vivo : What Cell Culture Models Tell Us about Infectious Proteins. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-491926
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Krauss, Sybille& Vorberg, Ina. Prions Ex Vivo : What Cell Culture Models Tell Us about Infectious Proteins. International Journal of Cell Biology No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-491926
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Krauss, Sybille& Vorberg, Ina. Prions Ex Vivo : What Cell Culture Models Tell Us about Infectious Proteins. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-491926
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491926
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)