Prions Ex Vivo : What Cell Culture Models Tell Us about Infectious Proteins
Joint Authors
Source
International Journal of Cell Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Prions are unconventional infectious agents that are composed of misfolded aggregated prion protein.
Prions replicate their conformation by template-assisted conversion of the endogenous prion protein PrP.
Templated conversion of soluble proteins into protein aggregates is also a hallmark of other neurodegenerative diseases.
Alzheimer’s disease or Parkinson’s disease are not considered infectious diseases, although aggregate pathology appears to progress in a stereotypical fashion reminiscent of the spreading behavior ofmammalian prions.
While basic principles of prion formation have been studied extensively, it is still unclear what exactly drives PrP molecules into an infectious, self-templating conformation.
In this review, we discuss crucial steps in the life cycle of prions that have been revealed in ex vivo models.
Importantly, the persistent propagation of prions in mitotically active cells argues that cellular processes are in place that not only allow recruitment of cellular PrP into growing prion aggregates but also enable the multiplication of infectious seeds that are transmitted to daughter cells.
Comparison of prions with other protein aggregates demonstrates that not all the characteristics of prions are equally shared by prion-like aggregates.
Future experiments may reveal to which extent aggregation-prone proteins associated with other neurodegenerative diseases can copy the replication strategies of prions.
American Psychological Association (APA)
Krauss, Sybille& Vorberg, Ina. 2013. Prions Ex Vivo : What Cell Culture Models Tell Us about Infectious Proteins. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-491926
Modern Language Association (MLA)
Krauss, Sybille& Vorberg, Ina. Prions Ex Vivo : What Cell Culture Models Tell Us about Infectious Proteins. International Journal of Cell Biology No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-491926
American Medical Association (AMA)
Krauss, Sybille& Vorberg, Ina. Prions Ex Vivo : What Cell Culture Models Tell Us about Infectious Proteins. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-491926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491926