Granulocyte Macrophage Colony Stimulating Factor Supplementation in Culture Media for Subfertile Women Undergoing Assisted Reproduction Technologies : A Systematic Review
المؤلفون المشاركون
Siristatidis, Charalampos
Creatsa, Maria
Glujovsky, Demián
Vogiatzi, Paraskevi
Salamalekis, George
Zoe, Iliodromiti
Chrelias, Charalampos
Vrachnis, Nicolaos
المصدر
International Journal of Endocrinology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-21
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Granulocyte macrophage colony stimulating factor (GM-CSF) is a cytokine/growth factor produced by epithelial cells that exerts embryotrophic effects during the early stages of embryo development.
We performed a systematic review, and six studies that were performed in humans undergoing assisted reproduction technologies (ART) were located.
We wanted to evaluate if embryo culture media supplementation with GM-CSF could improve success rates.
As the type of studies and the outcome parameters investigated were heterogeneous, we decided not to perform a meta-analysis.
Most of them had a trend favoring the supplementation with GM-CSF, when outcomes were measured in terms of increased percentage of good-quality embryos reaching the blastocyst stage, improved hatching initiation and number of cells in the blastocyst, and reduction of cell death.
However, no statistically significant differences were found in implantation and pregnancy rates in all apart from one large multicenter trial, which reported favorable outcomes, in terms of implantation and live birth rates.
We propose properly conducted and adequately powered randomized controlled trials (RCTs) to further validate and extrapolate the current findings with the live birth rate to be the primary outcome measure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Siristatidis, Charalampos& Vogiatzi, Paraskevi& Salamalekis, George& Creatsa, Maria& Vrachnis, Nicolaos& Glujovsky, Demián…[et al.]. 2013. Granulocyte Macrophage Colony Stimulating Factor Supplementation in Culture Media for Subfertile Women Undergoing Assisted Reproduction Technologies : A Systematic Review. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-491967
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Siristatidis, Charalampos…[et al.]. Granulocyte Macrophage Colony Stimulating Factor Supplementation in Culture Media for Subfertile Women Undergoing Assisted Reproduction Technologies : A Systematic Review. International Journal of Endocrinology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-491967
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Siristatidis, Charalampos& Vogiatzi, Paraskevi& Salamalekis, George& Creatsa, Maria& Vrachnis, Nicolaos& Glujovsky, Demián…[et al.]. Granulocyte Macrophage Colony Stimulating Factor Supplementation in Culture Media for Subfertile Women Undergoing Assisted Reproduction Technologies : A Systematic Review. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-491967
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491967
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر