Granulocyte Macrophage Colony Stimulating Factor Supplementation in Culture Media for Subfertile Women Undergoing Assisted Reproduction Technologies : A Systematic Review
Joint Authors
Siristatidis, Charalampos
Creatsa, Maria
Glujovsky, Demián
Vogiatzi, Paraskevi
Salamalekis, George
Zoe, Iliodromiti
Chrelias, Charalampos
Vrachnis, Nicolaos
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Granulocyte macrophage colony stimulating factor (GM-CSF) is a cytokine/growth factor produced by epithelial cells that exerts embryotrophic effects during the early stages of embryo development.
We performed a systematic review, and six studies that were performed in humans undergoing assisted reproduction technologies (ART) were located.
We wanted to evaluate if embryo culture media supplementation with GM-CSF could improve success rates.
As the type of studies and the outcome parameters investigated were heterogeneous, we decided not to perform a meta-analysis.
Most of them had a trend favoring the supplementation with GM-CSF, when outcomes were measured in terms of increased percentage of good-quality embryos reaching the blastocyst stage, improved hatching initiation and number of cells in the blastocyst, and reduction of cell death.
However, no statistically significant differences were found in implantation and pregnancy rates in all apart from one large multicenter trial, which reported favorable outcomes, in terms of implantation and live birth rates.
We propose properly conducted and adequately powered randomized controlled trials (RCTs) to further validate and extrapolate the current findings with the live birth rate to be the primary outcome measure.
American Psychological Association (APA)
Siristatidis, Charalampos& Vogiatzi, Paraskevi& Salamalekis, George& Creatsa, Maria& Vrachnis, Nicolaos& Glujovsky, Demián…[et al.]. 2013. Granulocyte Macrophage Colony Stimulating Factor Supplementation in Culture Media for Subfertile Women Undergoing Assisted Reproduction Technologies : A Systematic Review. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-491967
Modern Language Association (MLA)
Siristatidis, Charalampos…[et al.]. Granulocyte Macrophage Colony Stimulating Factor Supplementation in Culture Media for Subfertile Women Undergoing Assisted Reproduction Technologies : A Systematic Review. International Journal of Endocrinology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-491967
American Medical Association (AMA)
Siristatidis, Charalampos& Vogiatzi, Paraskevi& Salamalekis, George& Creatsa, Maria& Vrachnis, Nicolaos& Glujovsky, Demián…[et al.]. Granulocyte Macrophage Colony Stimulating Factor Supplementation in Culture Media for Subfertile Women Undergoing Assisted Reproduction Technologies : A Systematic Review. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-491967
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491967