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Pomegranate Polyphenols Lower Lipid Peroxidation in Adults with Type 2 Diabetes but Have No Effects in Healthy Volunteers : A Pilot Study
المؤلفون المشاركون
Lyons, Timothy J.
Basu, Arpita
Betts, Nancy M.
Newman, Emily D.
Bryant, Alecia L.
المصدر
Journal of Nutrition and Metabolism
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aims.
To examine the antioxidant and anti-inflammatory effects of pomegranate polyphenols in obese patients with type 2 diabetes (T2DM) (n=8) and in healthy nondiabetic controls (n=9).
Methods.
Participants received 2 capsules of pomegranate polyphenols (POMx, 1 capsule = 753 mg polyphenols) daily for 4 weeks.
Blood draws and anthropometrics were performed at baseline and at 4 weeks of the study.
Results.
Pomegranate polyphenols in healthy controls and in T2DM patients did not significantly affect body weight and blood pressure, glucose and lipids.
Among clinical safety profiles, serum electrolytes, renal function tests, and hematological profiles were not significantly affected by POMx supplementation.
However, aspartate aminotransferase (AST) showed a significant increase in healthy controls, while alanine aminotransferase (ALT) was significantly decreased in T2DM patients at 4 weeks (P<0.05), though values remained within the normal ranges.
Among the biomarkers of lipid oxidation and inflammation, oxidized LDL and serum C-reactive protein (CRP) did not differ at 4 weeks in either group, while pomegranate polyphenols significantly decreased malondialdehyde (MDA) and hydroxynonenal (HNE) only in the diabetic group versus baseline (P<0.05).
Conclusions.
POMx reduces lipid peroxidation in patients with T2DM, but with no effects in healthy controls, and specifically modulates liver enzymes in diabetic and nondiabetic subjects.
Larger clinical trials are merited.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Basu, Arpita& Newman, Emily D.& Bryant, Alecia L.& Lyons, Timothy J.& Betts, Nancy M.. 2013. Pomegranate Polyphenols Lower Lipid Peroxidation in Adults with Type 2 Diabetes but Have No Effects in Healthy Volunteers : A Pilot Study. Journal of Nutrition and Metabolism،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-492247
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Basu, Arpita…[et al.]. Pomegranate Polyphenols Lower Lipid Peroxidation in Adults with Type 2 Diabetes but Have No Effects in Healthy Volunteers : A Pilot Study. Journal of Nutrition and Metabolism No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-492247
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Basu, Arpita& Newman, Emily D.& Bryant, Alecia L.& Lyons, Timothy J.& Betts, Nancy M.. Pomegranate Polyphenols Lower Lipid Peroxidation in Adults with Type 2 Diabetes but Have No Effects in Healthy Volunteers : A Pilot Study. Journal of Nutrition and Metabolism. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-492247
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492247
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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