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The Compatible Solute Ectoine Reduces the Exacerbating Effect of Environmental Model Particles on the Immune Response of the Airways
المؤلفون المشاركون
Gotić, Marijan
Kroker, Matthias
Unfried, Klaus
Autengruber, Andrea
Sydlik, Ulrich
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-12
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Exposure of humans to particulate air pollution has been correlated with the incidence and aggravation of allergic airway diseases.
In predisposed individuals, inhalation of environmental particles can lead to an exacerbation of immune responses.
Previous studies demonstrated a beneficial effect of the compatible solute ectoine on lung inflammation in rats exposed to carbon nanoparticles (CNP) as a model of environmental particle exposure.
In the current study we investigated the effect of such a treatment on airway inflammation in a mouse allergy model.
Ectoine in nonsensitized animals significantly reduced the neutrophilic lung inflammation after CNP exposure.
This effect was accompanied by a reduction of inflammatory factors in the bronchoalveolar lavage.
Reduced IL-6 levels in the serum also indicate the effects of ectoine on systemic inflammation.
In sensitized animals, an aggravation of the immune response was observed when animals were exposed to CNP prior to antigen provocation.
The coadministration of ectoine together with the particles significantly reduced this exacerbation.
The data indicate the role of neutrophilic lung inflammation in the exacerbation of allergic airway responses.
Moreover, the data suggest to use ectoine as a preventive treatment to avoid the exacerbation of allergic airway responses induced by environmental air pollution.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Unfried, Klaus& Kroker, Matthias& Autengruber, Andrea& Gotić, Marijan& Sydlik, Ulrich. 2014. The Compatible Solute Ectoine Reduces the Exacerbating Effect of Environmental Model Particles on the Immune Response of the Airways. Journal of Allergy،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-492260
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Unfried, Klaus…[et al.]. The Compatible Solute Ectoine Reduces the Exacerbating Effect of Environmental Model Particles on the Immune Response of the Airways. Journal of Allergy No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-492260
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Unfried, Klaus& Kroker, Matthias& Autengruber, Andrea& Gotić, Marijan& Sydlik, Ulrich. The Compatible Solute Ectoine Reduces the Exacerbating Effect of Environmental Model Particles on the Immune Response of the Airways. Journal of Allergy. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-492260
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492260
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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