The Compatible Solute Ectoine Reduces the Exacerbating Effect of Environmental Model Particles on the Immune Response of the Airways
Joint Authors
Gotić, Marijan
Kroker, Matthias
Unfried, Klaus
Autengruber, Andrea
Sydlik, Ulrich
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Exposure of humans to particulate air pollution has been correlated with the incidence and aggravation of allergic airway diseases.
In predisposed individuals, inhalation of environmental particles can lead to an exacerbation of immune responses.
Previous studies demonstrated a beneficial effect of the compatible solute ectoine on lung inflammation in rats exposed to carbon nanoparticles (CNP) as a model of environmental particle exposure.
In the current study we investigated the effect of such a treatment on airway inflammation in a mouse allergy model.
Ectoine in nonsensitized animals significantly reduced the neutrophilic lung inflammation after CNP exposure.
This effect was accompanied by a reduction of inflammatory factors in the bronchoalveolar lavage.
Reduced IL-6 levels in the serum also indicate the effects of ectoine on systemic inflammation.
In sensitized animals, an aggravation of the immune response was observed when animals were exposed to CNP prior to antigen provocation.
The coadministration of ectoine together with the particles significantly reduced this exacerbation.
The data indicate the role of neutrophilic lung inflammation in the exacerbation of allergic airway responses.
Moreover, the data suggest to use ectoine as a preventive treatment to avoid the exacerbation of allergic airway responses induced by environmental air pollution.
American Psychological Association (APA)
Unfried, Klaus& Kroker, Matthias& Autengruber, Andrea& Gotić, Marijan& Sydlik, Ulrich. 2014. The Compatible Solute Ectoine Reduces the Exacerbating Effect of Environmental Model Particles on the Immune Response of the Airways. Journal of Allergy،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-492260
Modern Language Association (MLA)
Unfried, Klaus…[et al.]. The Compatible Solute Ectoine Reduces the Exacerbating Effect of Environmental Model Particles on the Immune Response of the Airways. Journal of Allergy No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-492260
American Medical Association (AMA)
Unfried, Klaus& Kroker, Matthias& Autengruber, Andrea& Gotić, Marijan& Sydlik, Ulrich. The Compatible Solute Ectoine Reduces the Exacerbating Effect of Environmental Model Particles on the Immune Response of the Airways. Journal of Allergy. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-492260
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492260