![](/images/graphics-bg.png)
Effects of Chlorophenoxy Herbicides and Their Main Transformation Products on DNA Damage and Acetylcholinesterase Activity
المؤلفون المشاركون
Benfeito, Sofia
Garrido, E. Manuela
Sottomayor, M. J.
Borges, Fernanda
Silva, Tiago
Garrido, Jorge
Andrade, Paula B.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Persistent pesticide transformation products (TPs) are increasingly being detected among different environmental compartments, including groundwater and surface water.
However, there is no sufficient experimental data on their toxicological potential to assess the risk associated with TPs, even if their occurrence is known.
In this study, the interaction of chlorophenoxy herbicides (MCPA, mecoprop, 2,4-D and dichlorprop) and their main transformation products with calf thymus DNA by UV-visible absorption spectroscopy has been assessed.
Additionally, the toxicity of the chlorophenoxy herbicides and TPs was also assessed evaluating the inhibition of acetylcholinesterase activity.
On the basis of the results found, it seems that AChE is not the main target of chlorophenoxy herbicides and their TPs.
However, the results found showed that the transformation products displayed a higher inhibitory activity when compared with the parent herbicides.
The results obtained in the DNA interaction studies showed, in general, a slight effect on the stability of the double helix.
However, the data found for 4-chloro-2-methyl-6-nitrophenol suggest that this transformation product can interact with DNA through a noncovalent mode.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Benfeito, Sofia& Silva, Tiago& Garrido, Jorge& Andrade, Paula B.& Sottomayor, M. J.& Borges, Fernanda…[et al.]. 2014. Effects of Chlorophenoxy Herbicides and Their Main Transformation Products on DNA Damage and Acetylcholinesterase Activity. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-492311
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Benfeito, Sofia…[et al.]. Effects of Chlorophenoxy Herbicides and Their Main Transformation Products on DNA Damage and Acetylcholinesterase Activity. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-492311
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Benfeito, Sofia& Silva, Tiago& Garrido, Jorge& Andrade, Paula B.& Sottomayor, M. J.& Borges, Fernanda…[et al.]. Effects of Chlorophenoxy Herbicides and Their Main Transformation Products on DNA Damage and Acetylcholinesterase Activity. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-492311
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492311
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)