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Effects of Chlorophenoxy Herbicides and Their Main Transformation Products on DNA Damage and Acetylcholinesterase Activity
Joint Authors
Benfeito, Sofia
Garrido, E. Manuela
Sottomayor, M. J.
Borges, Fernanda
Silva, Tiago
Garrido, Jorge
Andrade, Paula B.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Persistent pesticide transformation products (TPs) are increasingly being detected among different environmental compartments, including groundwater and surface water.
However, there is no sufficient experimental data on their toxicological potential to assess the risk associated with TPs, even if their occurrence is known.
In this study, the interaction of chlorophenoxy herbicides (MCPA, mecoprop, 2,4-D and dichlorprop) and their main transformation products with calf thymus DNA by UV-visible absorption spectroscopy has been assessed.
Additionally, the toxicity of the chlorophenoxy herbicides and TPs was also assessed evaluating the inhibition of acetylcholinesterase activity.
On the basis of the results found, it seems that AChE is not the main target of chlorophenoxy herbicides and their TPs.
However, the results found showed that the transformation products displayed a higher inhibitory activity when compared with the parent herbicides.
The results obtained in the DNA interaction studies showed, in general, a slight effect on the stability of the double helix.
However, the data found for 4-chloro-2-methyl-6-nitrophenol suggest that this transformation product can interact with DNA through a noncovalent mode.
American Psychological Association (APA)
Benfeito, Sofia& Silva, Tiago& Garrido, Jorge& Andrade, Paula B.& Sottomayor, M. J.& Borges, Fernanda…[et al.]. 2014. Effects of Chlorophenoxy Herbicides and Their Main Transformation Products on DNA Damage and Acetylcholinesterase Activity. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-492311
Modern Language Association (MLA)
Benfeito, Sofia…[et al.]. Effects of Chlorophenoxy Herbicides and Their Main Transformation Products on DNA Damage and Acetylcholinesterase Activity. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-492311
American Medical Association (AMA)
Benfeito, Sofia& Silva, Tiago& Garrido, Jorge& Andrade, Paula B.& Sottomayor, M. J.& Borges, Fernanda…[et al.]. Effects of Chlorophenoxy Herbicides and Their Main Transformation Products on DNA Damage and Acetylcholinesterase Activity. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-492311
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492311