![](/images/graphics-bg.png)
Potential Synergy Activity of the Novel Ceragenin, CSA-13, against Carbapenem-Resistant Acinetobacter baumannii Strains Isolated from Bacteremia Patients
المؤلفون المشاركون
Akcali, Alper
Savage, Paul B.
Ozbek-Celik, Berna
Bozkurt-Guzel, Cagla
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-24
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Carbapenem-resistant Acinetobacter baumannii is an important cause of nosocomial infections, particularly in patients in the intensive care units.
As chronic infections are difficult to treat, attempts have been made to discover new antimicrobials.
Ceragenins, designed to mimic the activities of antimicrobial peptides, are a new class of antimicrobial agents.
In this study, the in vitro activities of CSA-13 either alone or in combination with colistin (sulphate), tobramycin, and ciprofloxacin were investigated using 60 carbapenem-resistant A.
baumannii strains isolated from bacteremia patients blood specimens.
MICs and MBCs were determined by microbroth dilution technique.
Combinations were assessed by using checkerboard technique.
The MIC50 values (mg/L) of CSA-13, colistin, tobramycin, and ciprofloxacin were 2, 1, 1.25, and 80, respectively.
The MIC90 (mg/L) of CSA-13 and colistin were 8 and 4.
The MBCs were equal to or twice greater than those of the MICs.
Synergistic interactions were mostly seen with CSA-13-colistin (55%), whereas the least synergistic interactions were observed in the CSA-13-tobramycin (35%) combination.
No antagonism was observed.
CSA-13 appears to be a good candidate for further investigations in the treatment of A.
baumannii infections.
However, future studies should be performed to correlate the safety, efficacy, and pharmacokinetic parameters of this molecule.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bozkurt-Guzel, Cagla& Savage, Paul B.& Akcali, Alper& Ozbek-Celik, Berna. 2014. Potential Synergy Activity of the Novel Ceragenin, CSA-13, against Carbapenem-Resistant Acinetobacter baumannii Strains Isolated from Bacteremia Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-492415
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bozkurt-Guzel, Cagla…[et al.]. Potential Synergy Activity of the Novel Ceragenin, CSA-13, against Carbapenem-Resistant Acinetobacter baumannii Strains Isolated from Bacteremia Patients. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-492415
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bozkurt-Guzel, Cagla& Savage, Paul B.& Akcali, Alper& Ozbek-Celik, Berna. Potential Synergy Activity of the Novel Ceragenin, CSA-13, against Carbapenem-Resistant Acinetobacter baumannii Strains Isolated from Bacteremia Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-492415
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492415
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)