Potential Synergy Activity of the Novel Ceragenin, CSA-13, against Carbapenem-Resistant Acinetobacter baumannii Strains Isolated from Bacteremia Patients
Joint Authors
Akcali, Alper
Savage, Paul B.
Ozbek-Celik, Berna
Bozkurt-Guzel, Cagla
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Carbapenem-resistant Acinetobacter baumannii is an important cause of nosocomial infections, particularly in patients in the intensive care units.
As chronic infections are difficult to treat, attempts have been made to discover new antimicrobials.
Ceragenins, designed to mimic the activities of antimicrobial peptides, are a new class of antimicrobial agents.
In this study, the in vitro activities of CSA-13 either alone or in combination with colistin (sulphate), tobramycin, and ciprofloxacin were investigated using 60 carbapenem-resistant A.
baumannii strains isolated from bacteremia patients blood specimens.
MICs and MBCs were determined by microbroth dilution technique.
Combinations were assessed by using checkerboard technique.
The MIC50 values (mg/L) of CSA-13, colistin, tobramycin, and ciprofloxacin were 2, 1, 1.25, and 80, respectively.
The MIC90 (mg/L) of CSA-13 and colistin were 8 and 4.
The MBCs were equal to or twice greater than those of the MICs.
Synergistic interactions were mostly seen with CSA-13-colistin (55%), whereas the least synergistic interactions were observed in the CSA-13-tobramycin (35%) combination.
No antagonism was observed.
CSA-13 appears to be a good candidate for further investigations in the treatment of A.
baumannii infections.
However, future studies should be performed to correlate the safety, efficacy, and pharmacokinetic parameters of this molecule.
American Psychological Association (APA)
Bozkurt-Guzel, Cagla& Savage, Paul B.& Akcali, Alper& Ozbek-Celik, Berna. 2014. Potential Synergy Activity of the Novel Ceragenin, CSA-13, against Carbapenem-Resistant Acinetobacter baumannii Strains Isolated from Bacteremia Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-492415
Modern Language Association (MLA)
Bozkurt-Guzel, Cagla…[et al.]. Potential Synergy Activity of the Novel Ceragenin, CSA-13, against Carbapenem-Resistant Acinetobacter baumannii Strains Isolated from Bacteremia Patients. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-492415
American Medical Association (AMA)
Bozkurt-Guzel, Cagla& Savage, Paul B.& Akcali, Alper& Ozbek-Celik, Berna. Potential Synergy Activity of the Novel Ceragenin, CSA-13, against Carbapenem-Resistant Acinetobacter baumannii Strains Isolated from Bacteremia Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-492415
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492415