Higher Prostate Weight Is Inversely Associated with Gleason Score Upgrading in Radical Prostatectomy Specimens
المؤلفون المشاركون
Freitas, Leandro L. L.
Denardi, Fernandes
Reis, Leonardo Oliveira
Billis, Athanase
Zani, Emerson Luis
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Protective factors against Gleason upgrading and its impact on outcomes after surgery warrant better definition.
Patients and Methods.
Consecutive 343 patients were categorized at biopsy (BGS) and prostatectomy (PGS) as Gleason score, ≤6, 7, and ≥8; 94 patients (27.4%) had PSA recurrence, mean followup 80.2 months (median 99).
Independent predictors of Gleason upgrading (logistic regression) and disease-free survival (DFS) (Kaplan-Meier, log-rank) were determined.
Results.
Gleason discordance was 45.7% (37.32% upgrading and 8.45% downgrading).
Upgrading risk decreased by 2.4% for each 1 g of prostate weight increment, while it increased by 10.2% for every 1 ng/mL of PSA, 72.0% for every 0.1 unity of PSA density and was 21 times higher for those with BGS 7.
Gleason upgrading showed increased clinical stage (P=0.019), higher tumor extent (P=0.009), extraprostatic extension (P=0.04), positive surgical margins (P<0.001), seminal vesicle invasion (P=0.003), less “insignificant” tumors (P<0.001), and also worse DFS, χ2=4.28, df=1, P=0.039.
However, when setting the final Gleason score (BGS ≤6 to PGS 7 versus BGS 7 to PGS 7), avoiding allocation bias, DFS impact is not confirmed, χ2=0.40, df=1, P=0.530.Conclusions.
Gleason upgrading is substantial and confers worse outcomes.
Prostate weight is inversely related to upgrading and its protective effect warrants further evaluation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Reis, Leonardo Oliveira& Zani, Emerson Luis& Freitas, Leandro L. L.& Denardi, Fernandes& Billis, Athanase. 2013. Higher Prostate Weight Is Inversely Associated with Gleason Score Upgrading in Radical Prostatectomy Specimens. Advances in Urology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-492434
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Reis, Leonardo Oliveira…[et al.]. Higher Prostate Weight Is Inversely Associated with Gleason Score Upgrading in Radical Prostatectomy Specimens. Advances in Urology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-492434
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Reis, Leonardo Oliveira& Zani, Emerson Luis& Freitas, Leandro L. L.& Denardi, Fernandes& Billis, Athanase. Higher Prostate Weight Is Inversely Associated with Gleason Score Upgrading in Radical Prostatectomy Specimens. Advances in Urology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-492434
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492434
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر