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Higher Prostate Weight Is Inversely Associated with Gleason Score Upgrading in Radical Prostatectomy Specimens
Joint Authors
Freitas, Leandro L. L.
Denardi, Fernandes
Reis, Leonardo Oliveira
Billis, Athanase
Zani, Emerson Luis
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Protective factors against Gleason upgrading and its impact on outcomes after surgery warrant better definition.
Patients and Methods.
Consecutive 343 patients were categorized at biopsy (BGS) and prostatectomy (PGS) as Gleason score, ≤6, 7, and ≥8; 94 patients (27.4%) had PSA recurrence, mean followup 80.2 months (median 99).
Independent predictors of Gleason upgrading (logistic regression) and disease-free survival (DFS) (Kaplan-Meier, log-rank) were determined.
Results.
Gleason discordance was 45.7% (37.32% upgrading and 8.45% downgrading).
Upgrading risk decreased by 2.4% for each 1 g of prostate weight increment, while it increased by 10.2% for every 1 ng/mL of PSA, 72.0% for every 0.1 unity of PSA density and was 21 times higher for those with BGS 7.
Gleason upgrading showed increased clinical stage (P=0.019), higher tumor extent (P=0.009), extraprostatic extension (P=0.04), positive surgical margins (P<0.001), seminal vesicle invasion (P=0.003), less “insignificant” tumors (P<0.001), and also worse DFS, χ2=4.28, df=1, P=0.039.
However, when setting the final Gleason score (BGS ≤6 to PGS 7 versus BGS 7 to PGS 7), avoiding allocation bias, DFS impact is not confirmed, χ2=0.40, df=1, P=0.530.Conclusions.
Gleason upgrading is substantial and confers worse outcomes.
Prostate weight is inversely related to upgrading and its protective effect warrants further evaluation.
American Psychological Association (APA)
Reis, Leonardo Oliveira& Zani, Emerson Luis& Freitas, Leandro L. L.& Denardi, Fernandes& Billis, Athanase. 2013. Higher Prostate Weight Is Inversely Associated with Gleason Score Upgrading in Radical Prostatectomy Specimens. Advances in Urology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-492434
Modern Language Association (MLA)
Reis, Leonardo Oliveira…[et al.]. Higher Prostate Weight Is Inversely Associated with Gleason Score Upgrading in Radical Prostatectomy Specimens. Advances in Urology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-492434
American Medical Association (AMA)
Reis, Leonardo Oliveira& Zani, Emerson Luis& Freitas, Leandro L. L.& Denardi, Fernandes& Billis, Athanase. Higher Prostate Weight Is Inversely Associated with Gleason Score Upgrading in Radical Prostatectomy Specimens. Advances in Urology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-492434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492434