At the Start of the Sarcomere : A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis
المؤلفون المشاركون
Pilgrim, David B.
Myhre, J. Layne
المصدر
Biochemistry Research International
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-01-30
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
The development of striated muscle in vertebrates requires the assembly of contractile myofibrils, consisting of highly ordered bundles of protein filaments.
Myofibril formation occurs by the stepwise addition of complex proteins, a process that is mediated by a variety of molecular chaperones and quality control factors.
Most notably, myosin of the thick filament requires specialized chaperone activity during late myofibrillogenesis, including that of Hsp90 and its cofactor, Unc45b.
Unc45b has been proposed to act exclusively as an adaptor molecule, stabilizing interactions between Hsp90 and myosin; however, recent discoveries in zebrafish and C.
elegans suggest the possibility of an earlier role for Unc45b during myofibrillogenesis.
This role may involve functional control of nonmuscle myosins during the earliest stages of myogenesis, when premyofibril scaffolds are first formed from dynamic cytoskeletal actin.
This paper will outline several lines of evidence that converge to build a model for Unc45b activity during early myofibrillogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Myhre, J. Layne& Pilgrim, David B.. 2012. At the Start of the Sarcomere : A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-492516
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Myhre, J. Layne& Pilgrim, David B.. At the Start of the Sarcomere : A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis. Biochemistry Research International No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-492516
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Myhre, J. Layne& Pilgrim, David B.. At the Start of the Sarcomere : A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis. Biochemistry Research International. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-492516
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492516
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر