At the Start of the Sarcomere : A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis
Joint Authors
Pilgrim, David B.
Myhre, J. Layne
Source
Biochemistry Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-30
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The development of striated muscle in vertebrates requires the assembly of contractile myofibrils, consisting of highly ordered bundles of protein filaments.
Myofibril formation occurs by the stepwise addition of complex proteins, a process that is mediated by a variety of molecular chaperones and quality control factors.
Most notably, myosin of the thick filament requires specialized chaperone activity during late myofibrillogenesis, including that of Hsp90 and its cofactor, Unc45b.
Unc45b has been proposed to act exclusively as an adaptor molecule, stabilizing interactions between Hsp90 and myosin; however, recent discoveries in zebrafish and C.
elegans suggest the possibility of an earlier role for Unc45b during myofibrillogenesis.
This role may involve functional control of nonmuscle myosins during the earliest stages of myogenesis, when premyofibril scaffolds are first formed from dynamic cytoskeletal actin.
This paper will outline several lines of evidence that converge to build a model for Unc45b activity during early myofibrillogenesis.
American Psychological Association (APA)
Myhre, J. Layne& Pilgrim, David B.. 2012. At the Start of the Sarcomere : A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-492516
Modern Language Association (MLA)
Myhre, J. Layne& Pilgrim, David B.. At the Start of the Sarcomere : A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis. Biochemistry Research International No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-492516
American Medical Association (AMA)
Myhre, J. Layne& Pilgrim, David B.. At the Start of the Sarcomere : A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis. Biochemistry Research International. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-492516
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492516