Toxic Damage Increases Angiogenesis and Metastasis in Fibrotic Livers via PECAM-1
المؤلفون المشاركون
Van Cayzeele, Christina Jay
Strassburg, Christian P.
Sauerbruch, Tilman
Raskopf, Esther
Gonzalez Carmona, Maria Angeles
Schmitz, Volker
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-06
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Excessive ethanol consumption is one of the main causes of liver fibrosis.
However, direct effects of ethanol exposure on endothelial cells and their contribution to fibrogenesis and metastasis were not investigated.
Therefore we analysed whether ethanol directly affects endothelial cells and if this plays a role during fibrogenesis and metastasis in the liver.
Murine and human endothelial cells were exposed to ethanol for up to 72 hours.
In vitro, effects on VEGF, HIF-1alpha, PECAM-1, and endothelial cell functions were analysed.
In vivo, effects of continuous liver damage on blood vessel formation and metastasis were analysed by PECAM-1 immunohistochemistry.
Ethanol increased HIF-1alpha and VEGF levels in murine and human endothelial cells.
This resulted in enhanced intracellular signal transduction, and PECAM-1 expression as well as tube formation and wound healing.
In vivo, toxic liver damage increased angiogenesis during fibrogenesis.
Metastasis was also enhanced in fibrotic livers and located to PECAM-1 positive blood vessels compared to nonfibrotic mice.
In conclusion, ethanol had strong effects on endothelial cells, which—at least in part—led to a profibrotic and prometastatic environment mediated by PECAM-1.
Blockade of increased PECAM-1 expression could be a promising tool to inhibit fibrogenesis and metastasis in the liver.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Raskopf, Esther& Gonzalez Carmona, Maria Angeles& Van Cayzeele, Christina Jay& Strassburg, Christian P.& Sauerbruch, Tilman& Schmitz, Volker. 2014. Toxic Damage Increases Angiogenesis and Metastasis in Fibrotic Livers via PECAM-1. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-492583
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Raskopf, Esther…[et al.]. Toxic Damage Increases Angiogenesis and Metastasis in Fibrotic Livers via PECAM-1. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-492583
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Raskopf, Esther& Gonzalez Carmona, Maria Angeles& Van Cayzeele, Christina Jay& Strassburg, Christian P.& Sauerbruch, Tilman& Schmitz, Volker. Toxic Damage Increases Angiogenesis and Metastasis in Fibrotic Livers via PECAM-1. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-492583
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492583
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر