Atg14 : A Key Player in Orchestrating Autophagy

المؤلفون المشاركون

Ohsumi, Yoshinori
Obara, Keisuke

المصدر

International Journal of Cell Biology

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-10-13

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأحياء

الملخص EN

Phosphorylation of phosphatidylinositol (PtdIns) by a PtdIns 3-kinase is an essential process in autophagy.

Atg14, a specific subunit of one of the PtdIns 3-kinase complexes, targets the complex to the probable site of autophagosome formation, thereby, sorting the complex to function specifically in autophagy.

The N-terminal half of Atg14, containing coiled-coil domains, is required to form the PtdIns 3-kinase complex and target it to the proper site.

The C-terminal half of yeast Atg14 is suggested to be involved in the formation of a normal-sized autophagosome.

The C-terminal half of mammalian Atg14 contains the Barkor/Atg14(L) autophagosome-targeting sequence (BATS) domain that preferentially binds to the highly curved membranes containing PtdIns(3)P and is proposed to target the PtdIns 3-kinase complex efficiently to the isolation membrane.

Thus, the N- and C-terminal halves of Atg14 are likely to have an essential core function and a regulatory role, respectively.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Obara, Keisuke& Ohsumi, Yoshinori. 2011. Atg14 : A Key Player in Orchestrating Autophagy. International Journal of Cell Biology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-492623

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Obara, Keisuke& Ohsumi, Yoshinori. Atg14 : A Key Player in Orchestrating Autophagy. International Journal of Cell Biology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-492623

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Obara, Keisuke& Ohsumi, Yoshinori. Atg14 : A Key Player in Orchestrating Autophagy. International Journal of Cell Biology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-492623

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-492623