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Atg14 : A Key Player in Orchestrating Autophagy
Joint Authors
Ohsumi, Yoshinori
Obara, Keisuke
Source
International Journal of Cell Biology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Phosphorylation of phosphatidylinositol (PtdIns) by a PtdIns 3-kinase is an essential process in autophagy.
Atg14, a specific subunit of one of the PtdIns 3-kinase complexes, targets the complex to the probable site of autophagosome formation, thereby, sorting the complex to function specifically in autophagy.
The N-terminal half of Atg14, containing coiled-coil domains, is required to form the PtdIns 3-kinase complex and target it to the proper site.
The C-terminal half of yeast Atg14 is suggested to be involved in the formation of a normal-sized autophagosome.
The C-terminal half of mammalian Atg14 contains the Barkor/Atg14(L) autophagosome-targeting sequence (BATS) domain that preferentially binds to the highly curved membranes containing PtdIns(3)P and is proposed to target the PtdIns 3-kinase complex efficiently to the isolation membrane.
Thus, the N- and C-terminal halves of Atg14 are likely to have an essential core function and a regulatory role, respectively.
American Psychological Association (APA)
Obara, Keisuke& Ohsumi, Yoshinori. 2011. Atg14 : A Key Player in Orchestrating Autophagy. International Journal of Cell Biology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-492623
Modern Language Association (MLA)
Obara, Keisuke& Ohsumi, Yoshinori. Atg14 : A Key Player in Orchestrating Autophagy. International Journal of Cell Biology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-492623
American Medical Association (AMA)
Obara, Keisuke& Ohsumi, Yoshinori. Atg14 : A Key Player in Orchestrating Autophagy. International Journal of Cell Biology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-492623
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492623