The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis : The Myths and the Facts
المؤلفون المشاركون
Caielli, Paola
Maiolino, Giuseppe
Calò, Lorenzo A.
Rossitto, Giacomo
Bisogni, Valeria
Rossi, Gian Paolo
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-03
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The oxidative modification hypothesis of atherosclerosis, which assigns to oxidized low-density lipoproteins (LDLs) a crucial role in atherosclerosis initiation and progression, is still debated.
This review examines the role played by oxidized LDLs in atherogenesis taking into account data derived by studies based on molecular and clinical approaches.
Experimental data carried out in cellular lines and animal models of atherosclerosis support the proatherogenic role of oxidized LDLs: (a) through chemotactic and proliferating actions on monocytes/macrophages, inciting their transformation into foam cells; (b) through stimulation of smooth muscle cells (SMCs) recruitment and proliferation in the tunica intima; (c) through eliciting endothelial cells, SMCs, and macrophages apoptosis with ensuing necrotic core development.
Moreover, most of the experimental data on atherosclerosis-prone animals benefiting from antioxidant treatment points towards a link between oxidative stress and atherosclerosis.
The evidence coming from cohort studies demonstrating an association between oxidized LDLs and cardiovascular events, notwithstanding some discrepancies, seems to point towards a role of oxidized LDLs in atherosclerotic plaque development and destabilization.
Finally, the results of randomized clinical trials employing antioxidants completed up to date, despite demonstrating no benefits in healthy populations, suggest a benefit in high-risk patients.
In conclusion, available data seem to validate the oxidative modification hypothesis of atherosclerosis, although additional proofs are still needed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Maiolino, Giuseppe& Rossitto, Giacomo& Caielli, Paola& Bisogni, Valeria& Rossi, Gian Paolo& Calò, Lorenzo A.. 2013. The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis : The Myths and the Facts. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-492727
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Maiolino, Giuseppe…[et al.]. The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis : The Myths and the Facts. Mediators of Inflammation No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-492727
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Maiolino, Giuseppe& Rossitto, Giacomo& Caielli, Paola& Bisogni, Valeria& Rossi, Gian Paolo& Calò, Lorenzo A.. The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis : The Myths and the Facts. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-492727
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492727
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر