The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis : The Myths and the Facts
Joint Authors
Caielli, Paola
Maiolino, Giuseppe
Calò, Lorenzo A.
Rossitto, Giacomo
Bisogni, Valeria
Rossi, Gian Paolo
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The oxidative modification hypothesis of atherosclerosis, which assigns to oxidized low-density lipoproteins (LDLs) a crucial role in atherosclerosis initiation and progression, is still debated.
This review examines the role played by oxidized LDLs in atherogenesis taking into account data derived by studies based on molecular and clinical approaches.
Experimental data carried out in cellular lines and animal models of atherosclerosis support the proatherogenic role of oxidized LDLs: (a) through chemotactic and proliferating actions on monocytes/macrophages, inciting their transformation into foam cells; (b) through stimulation of smooth muscle cells (SMCs) recruitment and proliferation in the tunica intima; (c) through eliciting endothelial cells, SMCs, and macrophages apoptosis with ensuing necrotic core development.
Moreover, most of the experimental data on atherosclerosis-prone animals benefiting from antioxidant treatment points towards a link between oxidative stress and atherosclerosis.
The evidence coming from cohort studies demonstrating an association between oxidized LDLs and cardiovascular events, notwithstanding some discrepancies, seems to point towards a role of oxidized LDLs in atherosclerotic plaque development and destabilization.
Finally, the results of randomized clinical trials employing antioxidants completed up to date, despite demonstrating no benefits in healthy populations, suggest a benefit in high-risk patients.
In conclusion, available data seem to validate the oxidative modification hypothesis of atherosclerosis, although additional proofs are still needed.
American Psychological Association (APA)
Maiolino, Giuseppe& Rossitto, Giacomo& Caielli, Paola& Bisogni, Valeria& Rossi, Gian Paolo& Calò, Lorenzo A.. 2013. The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis : The Myths and the Facts. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-492727
Modern Language Association (MLA)
Maiolino, Giuseppe…[et al.]. The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis : The Myths and the Facts. Mediators of Inflammation No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-492727
American Medical Association (AMA)
Maiolino, Giuseppe& Rossitto, Giacomo& Caielli, Paola& Bisogni, Valeria& Rossi, Gian Paolo& Calò, Lorenzo A.. The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis : The Myths and the Facts. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-492727
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492727