The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis : The Myths and the Facts

Joint Authors

Caielli, Paola
Maiolino, Giuseppe
Calò, Lorenzo A.
Rossitto, Giacomo
Bisogni, Valeria
Rossi, Gian Paolo

Source

Mediators of Inflammation

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-10-03

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Diseases

Abstract EN

The oxidative modification hypothesis of atherosclerosis, which assigns to oxidized low-density lipoproteins (LDLs) a crucial role in atherosclerosis initiation and progression, is still debated.

This review examines the role played by oxidized LDLs in atherogenesis taking into account data derived by studies based on molecular and clinical approaches.

Experimental data carried out in cellular lines and animal models of atherosclerosis support the proatherogenic role of oxidized LDLs: (a) through chemotactic and proliferating actions on monocytes/macrophages, inciting their transformation into foam cells; (b) through stimulation of smooth muscle cells (SMCs) recruitment and proliferation in the tunica intima; (c) through eliciting endothelial cells, SMCs, and macrophages apoptosis with ensuing necrotic core development.

Moreover, most of the experimental data on atherosclerosis-prone animals benefiting from antioxidant treatment points towards a link between oxidative stress and atherosclerosis.

The evidence coming from cohort studies demonstrating an association between oxidized LDLs and cardiovascular events, notwithstanding some discrepancies, seems to point towards a role of oxidized LDLs in atherosclerotic plaque development and destabilization.

Finally, the results of randomized clinical trials employing antioxidants completed up to date, despite demonstrating no benefits in healthy populations, suggest a benefit in high-risk patients.

In conclusion, available data seem to validate the oxidative modification hypothesis of atherosclerosis, although additional proofs are still needed.

American Psychological Association (APA)

Maiolino, Giuseppe& Rossitto, Giacomo& Caielli, Paola& Bisogni, Valeria& Rossi, Gian Paolo& Calò, Lorenzo A.. 2013. The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis : The Myths and the Facts. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-492727

Modern Language Association (MLA)

Maiolino, Giuseppe…[et al.]. The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis : The Myths and the Facts. Mediators of Inflammation No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-492727

American Medical Association (AMA)

Maiolino, Giuseppe& Rossitto, Giacomo& Caielli, Paola& Bisogni, Valeria& Rossi, Gian Paolo& Calò, Lorenzo A.. The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis : The Myths and the Facts. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-492727

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-492727