The Use of Mouse Models for Understanding the Biology of Down Syndrome and Aging
المؤلفون المشاركون
Vacano, Guido N.
Duval, Nathan
Patterson, David
المصدر
Current Gerontology and Geriatrics Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-23
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
Down syndrome is a complex condition caused by trisomy of human chromosome 21.
The biology of aging may be different in individuals with Down syndrome; this is not well understood in any organism.
Because of its complexity, many aspects of Down syndrome must be studied either in humans or in animal models.
Studies in humans are essential but are limited for ethical and practical reasons.
Fortunately, genetically altered mice can serve as extremely useful models of Down syndrome, and progress in their production and analysis has been remarkable.
Here, we describe various mouse models that have been used to study Down syndrome.
We focus on segmental trisomies of mouse chromosome regions syntenic to human chromosome 21, mice in which individual genes have been introduced, or mice in which genes have been silenced by targeted mutagenesis.
We selected a limited number of genes for which considerable evidence links them to aspects of Down syndrome, and about which much is known regarding their function.
We focused on genes important for brain and cognitive function, and for the altered cancer spectrum seen in individuals with Down syndrome.
We conclude with observations on the usefulness of mouse models and speculation on future directions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vacano, Guido N.& Duval, Nathan& Patterson, David. 2012. The Use of Mouse Models for Understanding the Biology of Down Syndrome and Aging. Current Gerontology and Geriatrics Research،Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-492981
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vacano, Guido N.…[et al.]. The Use of Mouse Models for Understanding the Biology of Down Syndrome and Aging. Current Gerontology and Geriatrics Research No. 2012 (2012), pp.1-20.
https://search.emarefa.net/detail/BIM-492981
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vacano, Guido N.& Duval, Nathan& Patterson, David. The Use of Mouse Models for Understanding the Biology of Down Syndrome and Aging. Current Gerontology and Geriatrics Research. 2012. Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-492981
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492981
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر