The Use of Mouse Models for Understanding the Biology of Down Syndrome and Aging
Joint Authors
Vacano, Guido N.
Duval, Nathan
Patterson, David
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-23
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Down syndrome is a complex condition caused by trisomy of human chromosome 21.
The biology of aging may be different in individuals with Down syndrome; this is not well understood in any organism.
Because of its complexity, many aspects of Down syndrome must be studied either in humans or in animal models.
Studies in humans are essential but are limited for ethical and practical reasons.
Fortunately, genetically altered mice can serve as extremely useful models of Down syndrome, and progress in their production and analysis has been remarkable.
Here, we describe various mouse models that have been used to study Down syndrome.
We focus on segmental trisomies of mouse chromosome regions syntenic to human chromosome 21, mice in which individual genes have been introduced, or mice in which genes have been silenced by targeted mutagenesis.
We selected a limited number of genes for which considerable evidence links them to aspects of Down syndrome, and about which much is known regarding their function.
We focused on genes important for brain and cognitive function, and for the altered cancer spectrum seen in individuals with Down syndrome.
We conclude with observations on the usefulness of mouse models and speculation on future directions.
American Psychological Association (APA)
Vacano, Guido N.& Duval, Nathan& Patterson, David. 2012. The Use of Mouse Models for Understanding the Biology of Down Syndrome and Aging. Current Gerontology and Geriatrics Research،Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-492981
Modern Language Association (MLA)
Vacano, Guido N.…[et al.]. The Use of Mouse Models for Understanding the Biology of Down Syndrome and Aging. Current Gerontology and Geriatrics Research No. 2012 (2012), pp.1-20.
https://search.emarefa.net/detail/BIM-492981
American Medical Association (AMA)
Vacano, Guido N.& Duval, Nathan& Patterson, David. The Use of Mouse Models for Understanding the Biology of Down Syndrome and Aging. Current Gerontology and Geriatrics Research. 2012. Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-492981
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492981